Chemistry and Antitumor Evaluation of Selected Classical 2,4-Diaminoquinazoline Analogues of Folic Acid
A series of six 2,4-diaminoquinazoline analogues of folic acid which bear close structural resemblance to methotrexate, 1a, were synthesized by unequivocal routes.Three of these have not been described previously, while complete structural characterizatio