- Formal total synthesis of stigmatellin A
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An efficient and stereoselective approach for the formal total synthesis of Stigmatellin A has been described. The key steps involved in this synthesis are desymmetrization of the bicyclic olefin to introduce two methyl and two hydroxyl chiral centers, Fr
- Yadav,Revathi,Reddy, B.V. Subba
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- Asymmetric synthesis of stigmatellin and crocacin C
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The crystalline sulfone 18 (X-ray analysis), prepared from the monoacetate product [i.e., (+)-12; 98.2% ee] of the lipase PS-catalyzed acetylation of anti,anti-2,4-dimethyl-1,3,5-pentantriol (19a), has been elaborated either to crocacin C (10) or stigmatellin (1), thereby providing a convenient divergent access to these two natural antibiotics.
- Infante-Rodriguez, Carolina,Domon, Lisianne,Breuilles, Pascal,Uguen, Daniel
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p. 308 - 326
(2015/03/04)
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- Diastereo- and enantioselective total synthesis of stigmatellin A
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Stigmatellin A (1) isolated from the myxobacterium Stigmatella aurantiaca is a powerful inhibitor of electron transport in mitochondria and chloroplasts. The first highly diastereo- and enantioselective total synthesis of this important natural product is
- Enders, Dieter,Geibel, Gunter,Osborne, Simon
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p. 1302 - 1309
(2007/10/03)
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