276690-11-0

Basic information

• Product Name: 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone
• Synonyms: 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone;1-[2-hydroxy-4,6-dimethoxy-3-(methoxymethoxy)phenyl]propan-1-one
• CAS NO: 276690-11-0
• Molecular Formula: C₁₃H₁₈O₆
• Molecular Weight: 270.27842
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 276690-11-0.mol

Chemical Properties

• Boiling Point: 412.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.171±0.06 g/cm3(Predicted)
• Solubility: Dichloromethane, Ethyl Acetate
• PKA: 6.65±0.50(Predicted)
• CAS DataBase Reference: 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone(276690-11-0)
• EPA Substance Registry System: 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone(276690-11-0)

Safety Data

• Hazardous Substances Data: 276690-11-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone is used as a reactant for the preparation of Stigmatellin A (S686780), a compound with potential pharmaceutical applications. The synthesis of Stigmatellin A involves the use of this propanone derivative, highlighting its importance in the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
As a versatile organic compound, 1-[2-Hydroxy-4,6-diMethoxy-3-(MethoxyMethoxy)phenyl]-1-propanone can be utilized as a building block or intermediate in the synthesis of various other complex organic molecules. Its unique functional groups and structural features make it a valuable component in the creation of novel chemical entities with potential applications in different industries.
Used in Research and Development:
The compound's distinctive structure and properties make it an interesting subject for research and development in the fields of organic chemistry, medicinal chemistry, and materials science. Scientists and researchers can explore its potential applications, study its reactivity, and investigate its interactions with other molecules to develop new compounds with specific properties and functions.

Upstream product

• 94190-89-3 1-(2,3-Dihydroxy-4,6-dimethoxyphenyl)propan-1-one 
• 107-30-2 chloromethyl methyl ether 
• 500-99-2 3,5-dimethoxyphenol 
• 94190-87-1 1-(2-Hydroxy-4,6-dimethoxy-3-propionylphenyl)-1-propanone 
• 94190-88-2 Propionic acid 2-hydroxy-4,6-dimethoxy-3-propionylphenyl ester 
• 5333-45-9 1,2,3,5-tetramethoxybenzene 
• 89880-48-8 1-(2,3,4,6-tetramethoxyphenyl)propan-1-one 

Downstream Products

• 276690-20-1 (4S,5S,6S,7R)-8-Benzyloxy-5,7-dimethoxy-4,6-dimethyloctanoic acid 3,5-dimethoxy-2-methoxymethoxy-6-propionylphenyl ester 
• 276690-22-3 (2R,3S,4S,5S)-7-[5,7-dimethoxy-8-methoxymethoxy-3-methyl-4-oxo-4H-2-chromenyl]-2,4-dimethoxy-3,5-dimethylheptanol 
• 91682-96-1 stigmatellin A 
• 276690-21-2 2-[(3S,4S,5S,6R)-7-Benzyloxy-4,6-dimethylheptyl]-5,7-dimethoxy-8-methoxymethoxy-3-methyl-4H-1-benzopyran-4-one 

Relevant articles and documents

Formal total synthesis of stigmatellin A

An efficient and stereoselective approach for the formal total synthesis of Stigmatellin A has been described. The key steps involved in this synthesis are desymmetrization of the bicyclic olefin to introduce two methyl and two hydroxyl chiral centers, Fr

Asymmetric synthesis of stigmatellin and crocacin C

The crystalline sulfone 18 (X-ray analysis), prepared from the monoacetate product [i.e., (+)-12; 98.2% ee] of the lipase PS-catalyzed acetylation of anti,anti-2,4-dimethyl-1,3,5-pentantriol (19a), has been elaborated either to crocacin C (10) or stigmatellin (1), thereby providing a convenient divergent access to these two natural antibiotics.

Diastereo- and enantioselective total synthesis of stigmatellin A

Stigmatellin A (1) isolated from the myxobacterium Stigmatella aurantiaca is a powerful inhibitor of electron transport in mitochondria and chloroplasts. The first highly diastereo- and enantioselective total synthesis of this important natural product is