- PHTHALIMIDE DERIVATIVES AS TRPA1 MODULATORS
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The present invention provides TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1) modulators. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl.
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Page/Page column 25
(2009/10/22)
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- Reaction enthalpy of nucleophilic substitution of ethyl iodide in acetonitrile and its mechanistic significance
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Enthalpies of reaction for nucleophilic substitution of ethyl iodide have systematically been determined in acetonitrile. Through the concurrent analysis of empirical correlations between the reaction enthalpies and the specific interaction enthalpies for relevant anions with those between the logarithmic rates and the specific interaction enthalpies, partial desolvation accompanying activation has been deduced to be the major contributor to activation thermodynamic parameters, while the propensity of the reacting central atom in the nucleophilic anion plays a crucial role in determining reaction thermodynamic parameters. Semi-empirical molecular orbital calculations have supported these ideas. The application of the Marcus equation to the analysis of reaction characteristics in these reactions is discussed.
- Kondo, Yasuhiko,Tsukamoto, Tamio,Kimura, Naoko
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p. 1765 - 1769
(2007/10/03)
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- Characterization of Solute-Solvent Interaction at the Transition State by Thermodynamic and Quantum-mechanical Approaches. Reactions of Imidide Ions with Ethyl Iodide in Acetonitrile-Methanol
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Single-ion enthalpies of transfer for transition-state anions of imidide ion plus ethyl iodide reactions have been determined in acetonitrile-methanol mixtures and have been partitioned into component enthalpies. ΔtHANMeOHPHYS and ΔtHANMeOHSl.Statistical analysis led to the empirical correlation incorporating nucleophiles and transition-state anions between specific interaction enthalpies, ΔtHANMeOHSl and the number of methanol molecules participating in the specific interaction with the anion.The molecular mechanistic origin of the specific interaction has been rationalized by introducing the cocept of 'effective atomic charge on the oxygen atom' which has been derived through semi-empirical MNDO/PM3 molecular orbital calculations.
- Kondo, Yasuhiko,Nonaka, Osamu,Iwasaki, Kazuhiko,Kuwamoto, Tomoyuki,Takagi, Tatsuya
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p. 473 - 478
(2007/10/02)
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- Azo dyes from aminophthalimides and aniline, tetrahydroquinoline, and benzomorpholine couplers having thiosulfate groups
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Disclosed are azo dyes suitable for coloring polyamide material, particularly nylon carpet and which are prepared from aminophthalimides and couplers which are STR1 substituted with a thiosulfate ester group. These dyes produce yellow to blue shades and also color cellulose acetate fabrics and wool. The dyes have the general formula: STR2 wherein R2 and R4 are each selected from hydrogen and a large variety of organic substituents, the coupler C is an aniline, 1,2,3,4-tetrahydroquinoline, or benzomorpholine derivative wherein a Q-SSO3 M group is attached to the nitrogen thereof, Q being a lower alkylene or similar linking group, and M is Na+, K+, NH4+, or H+. The present dyes are superior in such properties as fastness to light, oxides of nitrogen, wash, ozone, sublimation, perspiration and crock, and exhibit good dyeability including migration, leveling, pH stability, and build.
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- Phthalimidyl-azo-tetrahydro-quinoline compounds
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Monoazo compounds containing a phthalimidyl diazo component the aromatic ring of which can be substituted with one or two substituents, and the nitrogen of which may be substituted, and a 1,2,3,4-tetrahydroquinoline disperse azo dye coupling component which contains at least one alkyl substituent, are useful for dyeing cellulose acetate, nylon, and especially polyester fibers on which the compounds exhibit good fastness and dyeability properties.
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- Phthalimidyl-azo-m-acylamido-n-substituted aniline compounds and polyester fibers dyed therewith
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Monoazo compounds containing a N-substituted-3- or 4-phthalimidyl diazo component and certain m-acylamido-N-substituted aniline residue coupling components produce bright scarlet to red shades on fibers of, for example, polyester, polyamide and cellulose esters, and exhibit improved dyeability properties and good to excellent fastness to light, high pH, sublimation and crocking.
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- Phthalimidyl-azo aniline type compounds and polyester fibers dyed therewith
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Monoazo compounds containing a phthalimidyl diazo component bearing on the aromatic ring thereof one or two substituents such as halogen or cyano and an aniline disperse azo dye coupling component which may have a substituent such as acetamido, are useful for dyeing polyester fibers on which the compounds exhibit good fastness and dyeability properties.
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