2778-84-9

Usage

Uses

Used in Pharmaceutical Industry:
N-Ethyl-3-nitrophthalimide is used as a precursor for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its chemical properties allow for the creation of diverse medicinal compounds with potential health benefits.
Used in Agrochemical Industry:
In the agrochemical sector, N-Ethyl-3-nitrophthalimide is utilized as a starting material for the production of agrochemicals, such as pesticides and herbicides. Its reactivity and stability make it suitable for the formulation of effective agricultural products.
Used as a Reagent in Organic Synthesis:
N-Ethyl-3-nitrophthalimide is employed as a reagent in the preparation of various organic compounds. Its capacity to undergo a wide range of chemical reactions facilitates the synthesis of complex organic molecules for research and industrial applications.

InChI:InChI=1/C10H8N2O4/c1-2-11-9(13)6-4-3-5-7(12(15)16)8(6)10(11)14/h3-5H,2H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 5329-95-3 potassium 3-nitrophthalimide 
• 603-11-2 3-nitrophthalic acid 
• 75-04-7 ethylamine 
• 75-03-6 ethyl iodide 
• 603-62-3 4-nitro-1H-isoindole-1,3(2H)-dione 

Relevant academic research and scientific papers

PHTHALIMIDE DERIVATIVES AS TRPA1 MODULATORS

The present invention provides TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1) modulators. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl.

Reaction enthalpy of nucleophilic substitution of ethyl iodide in acetonitrile and its mechanistic significance

Enthalpies of reaction for nucleophilic substitution of ethyl iodide have systematically been determined in acetonitrile. Through the concurrent analysis of empirical correlations between the reaction enthalpies and the specific interaction enthalpies for relevant anions with those between the logarithmic rates and the specific interaction enthalpies, partial desolvation accompanying activation has been deduced to be the major contributor to activation thermodynamic parameters, while the propensity of the reacting central atom in the nucleophilic anion plays a crucial role in determining reaction thermodynamic parameters. Semi-empirical molecular orbital calculations have supported these ideas. The application of the Marcus equation to the analysis of reaction characteristics in these reactions is discussed.

Characterization of Solute-Solvent Interaction at the Transition State by Thermodynamic and Quantum-mechanical Approaches. Reactions of Imidide Ions with Ethyl Iodide in Acetonitrile-Methanol

Single-ion enthalpies of transfer for transition-state anions of imidide ion plus ethyl iodide reactions have been determined in acetonitrile-methanol mixtures and have been partitioned into component enthalpies. ΔtHANMeOHPHYS and ΔtHANMeOHSl.Statistical analysis led to the empirical correlation incorporating nucleophiles and transition-state anions between specific interaction enthalpies, ΔtHANMeOHSl and the number of methanol molecules participating in the specific interaction with the anion.The molecular mechanistic origin of the specific interaction has been rationalized by introducing the cocept of 'effective atomic charge on the oxygen atom' which has been derived through semi-empirical MNDO/PM3 molecular orbital calculations.

Azo dyes from aminophthalimides and aniline, tetrahydroquinoline, and benzomorpholine couplers having thiosulfate groups

Disclosed are azo dyes suitable for coloring polyamide material, particularly nylon carpet and which are prepared from aminophthalimides and couplers which are STR1 substituted with a thiosulfate ester group. These dyes produce yellow to blue shades and also color cellulose acetate fabrics and wool. The dyes have the general formula: STR2 wherein R2 and R4 are each selected from hydrogen and a large variety of organic substituents, the coupler C is an aniline, 1,2,3,4-tetrahydroquinoline, or benzomorpholine derivative wherein a Q-SSO3 M group is attached to the nitrogen thereof, Q being a lower alkylene or similar linking group, and M is Na+, K+, NH4+, or H+. The present dyes are superior in such properties as fastness to light, oxides of nitrogen, wash, ozone, sublimation, perspiration and crock, and exhibit good dyeability including migration, leveling, pH stability, and build.

Phthalimidyl-azo-m-acylamido-n-substituted aniline compounds and polyester fibers dyed therewith

Monoazo compounds containing a N-substituted-3- or 4-phthalimidyl diazo component and certain m-acylamido-N-substituted aniline residue coupling components produce bright scarlet to red shades on fibers of, for example, polyester, polyamide and cellulose esters, and exhibit improved dyeability properties and good to excellent fastness to light, high pH, sublimation and crocking.

Phthalimidyl-azo-tetrahydro-quinoline compounds

Monoazo compounds containing a phthalimidyl diazo component the aromatic ring of which can be substituted with one or two substituents, and the nitrogen of which may be substituted, and a 1,2,3,4-tetrahydroquinoline disperse azo dye coupling component which contains at least one alkyl substituent, are useful for dyeing cellulose acetate, nylon, and especially polyester fibers on which the compounds exhibit good fastness and dyeability properties.

Phthalimidyl-azo aniline type compounds and polyester fibers dyed therewith

Monoazo compounds containing a phthalimidyl diazo component bearing on the aromatic ring thereof one or two substituents such as halogen or cyano and an aniline disperse azo dye coupling component which may have a substituent such as acetamido, are useful for dyeing polyester fibers on which the compounds exhibit good fastness and dyeability properties.