278183-10-1

Basic information

• Product Name: 5-Thiazolecarboxylic acid, 4-amino-, methyl ester
• Synonyms: 5-Thiazolecarboxylic acid, 4-amino-, methyl ester;5-Thiazolecarboxylicacid,4-amino-,methylester(9CI);4-Amino-5-thiazolecarboxylic acid methyl ester;Methyl 4-amino-5-thiazolecarboxylate;4-Amino-thiazole-5-carboxylicacidmethylester;Methyl 4-amino-1,3-thiazole-5-carboxylate;Methyl 4-aminothiazole-5-carboxylate;4-Amino-5-(methoxycarbonyl)-1,3-thiazole
• CAS NO: 278183-10-1
• Molecular Formula: C₅H₆N₂O₂S
• Molecular Weight: 158.17834
• Product Categories: CARBOXYLICESTER
• Mol File: 278183-10-1.mol

Chemical Properties

• Boiling Point: 291℃
• Flash Point: 130℃
• Appearance: /
• Density: 1.408
• Vapor Pressure: 0.00206mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.29±0.10(Predicted)
• CAS DataBase Reference: 5-Thiazolecarboxylic acid, 4-amino-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarboxylic acid, 4-amino-, methyl ester(278183-10-1)
• EPA Substance Registry System: 5-Thiazolecarboxylic acid, 4-amino-, methyl ester(278183-10-1)

Safety Data

• Hazardous Substances Data: 278183-10-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Thiazolecarboxylic acid, 4-amino-, methyl ester is used as a key intermediate in the synthesis of various carboxamides, which are known as enzyme inhibitors. These enzyme inhibitors play a crucial role in the development of drugs targeting specific enzymes involved in various diseases, including metabolic disorders, inflammation, and cancer.
Used in Chemical Industry:
In the chemical industry, 5-Thiazolecarboxylic acid, 4-amino-, methyl ester can be utilized as a building block for the synthesis of more complex organic molecules, such as pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure and functional groups make it a valuable component in the development of novel compounds with diverse applications.

InChI:InChI=1/C5H6N2O2S/c1-9-5(8)3-4(6)7-2-10-3/h2H,6H2,1H3

Upstream product

• 4428-98-2 N-cyanomethanimidic acid ethyl ester 
• 2365-48-2 Methyl thioglycolate 
• 60093-05-2 thiazole-5-carboxylic acid, 4-amino-2-methylthio-, methylester 
• 951804-64-1 4-amino-2-methanesulfonylthiazole-5-carboxylic acid methyl ester 

Downstream Products

• 852854-20-7 methyl 4-(4-chlorophenylaminocarbonothioylamino)-1,3-thiazole-5-carboxylate 
• 1243141-49-2 5-thiazolecarboxylic methyl ester 4-N-[(2,4-dimethyl-phenyl)-phosphonamidate methyl ester] 
• 7464-09-7 4H-thiazolo[4,5-d]pyrimidine-5,7-dione 
• 7464-09-7 [1,3]thiazolo[4,5-d]pyrimidine-5,7-diol 
• 1361340-65-9 methyl 4-{[(2-iodobenzyl)sulfonyl]amino}-1,3-thiazole-5-carboxylate 
• 1361340-64-8 methyl 4-{(2,2-difluoroethyl)[(2-iodobenzyl)sulfonyl]amino}-1,3-thiazole-5-carboxylate 

Relevant articles and documents

2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES

A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]

1,3-THIAZOLE-5-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS

This invention relates to novel 1, 3- thiazole-5 -carboxamide compounds of formula (I), pharmaceutical compositions containing such compounds, and the use of those compounds or compositions as cancer chemotherapeutic agents.

BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).