- Synthesis and insecticidal activity of 6,8-dichloro-quinazoline derivatives containing a sulfide substructure
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A series of 6,8-dichloro-quinazoline derivatives bearing a sulfide group was synthesized and characterized via 1H NMR, 13C NMR, IR and elemental analyses. All the compounds were tested for their insecticidal activity against Plutella xylostella in vitro. The results indicate that the synthesized compounds possess good insecticidal activity. Among these compounds, Vc, Vi, Vj, Vk and Vm displayed 75 %, 85 %, 80 %, 70 % and 63 % activities, respectively. These may prove useful as insecticidal agents.
- Wu, Jian,Bai, Song,Yue, Min,Luo, Li-Jun,Shi, Qin-Cai,Ma, Juan,Du, Xian-Li,Kang, Sheng-Hong,Hu, Deyu,Yang, Song
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- Synthesis of {2,3-dihydro-7-halopyrrolo-[(2,1-b)]-quinazolin-9-(1h)-one and 2,3-dihydro-5,7-dihalopyrrolo-[(2,1-b)]-quinazolin-9-(1h)-one}: New analogs of deoxyvasicinone
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A series of novel halogen-substituted deoxyvasicinone f2,3-dihydro-7- halopyrrolo-[(2,1-b)]-quinazolin-9-(1H)-one and 2,3-dihydro-5,7-dihalopyrrolo- [(2,1-b)]-quinazolin-9-(1H)-oneg derivatives was synthesized by condensation of halogenated anthranilic acids (2, 3, 4, 5) with 4-aminobutyric acid (6) in refluxing m-xylene over phosphorus pentoxide for 3 h to give the desired compounds (7a-7d). Taylor & Francis Group, LLC.
- Ojo, Babatunde,Chowdhury, Bejoy K.
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- Selenium-catalyzed intramolecular atom- And redox-economical transformation ofo-nitrotoluenes into anthranilic acids
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Anthranilic acids (AAs) are significant basic chemicals used in pharmaceuticals, agrochemicals, dyes, fragrances,etc. Superfluous steps are always involved in obtaining AAs. Herein, we demonstrate a straightforward strategy to transform abundanto-nitrotoluenes into biologically and pharmaceutically significant AAs without any extra reductants, oxidants and protecting groups. Various sensitive groups, such as halogens, sulfide, aldehyde, pyridines, quinolines,etc., can be tolerated in this transformation. A hundred-gram-scale operation is realized efficiently with almost quantitative selenium recycling. Further mechanistic studies and DFT calculations disclosed the proposed atom-exchange processes and the key roles of the selenium species.
- Jiang, Xuefeng,Li, Yiming,Lin, Zhenyang,Wang, Yuhong,Yang, Tilong
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supporting information
p. 2986 - 2991
(2021/05/05)
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- Anthranilic acid and derivatives thereof as well as synthesis method and application thereof
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In the reaction solvent, o-methyl (hetero) aryl nitro compound is taken as a reaction raw material and is used for water. The anthranilic acid and its derivatives are synthesized by the action of a catalyst, a base and an additive. The synthetic method has the advantages of cheap and easily available raw materials, simple reaction operation, high yield and excellent functional group tolerance, and provides a simple and efficient method for synthesizing o-aminobenzoic acid which is widely used in the aspects of dyes, medicines, pesticides, spices and the like. The invention further discloses the anthranilic acid and derivatives and application thereof, and has a wide application prospect.
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Paragraph 0086-0088
(2021/09/15)
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- PYRAZOLYL AMIDE COMPOUNDS AND USES THEREOF
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Disclosed is a pyrazole amide compound of a novel structure as represented by general formula I, wherein, each substituent group is as defined in the specification. The compound of general formula I has good insecticidal activity, and can be used for pest control.
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Paragraph 0099-0100
(2016/10/27)
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- Synthesis of 2,1-benzisoxazole-3(1H)-ones by base-mediated photochemical N-O bond-forming cyclization of 2-azidobenzoic acids
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The base-mediated photochemical cyclization of 2-azidobenzoic acids with the formation of 2,1-benzisoxazole-3(1H)-ones is reported. The optimization and scope of this cyclization reaction is discussed. It is shown that an essential step of the ring closure of 2-azidobenzoic acids is the formation and photolysis of 2-azidobenzoate anions.
- Dzhons, Daria Yu.,Budruev, Andrei V.
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supporting information
p. 874 - 881
(2016/07/06)
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- Synthesis of novel quinazolinone derivatives with methyl (E)-2-(3-methoxy)acrylate moiety
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A new series of quinazolinone derivatives with methyl (E)-2-(3-methoxy) acrylate moiety have been designed and synthesized. All target compounds had been identified by 1H NMR spectrum, IR spectrum and HR-MS (high resolution mass spectrum). Three target compounds (10a, 10e, 10h) were chosen to preliminarily test the antibacterial activities, the results showed that all three target compounds exhibited antibacterial activities against three bacterial strains (Proteobacteria, Salmonella, Colibacillus).
- Dong, Kui-Kui,Zhou, Hua-Hong,Guo, A-Rong,Chen, Tian,Wang, Yu-Liang
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p. 1039 - 1042
(2013/05/08)
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- INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1
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This invention relates to novel compounds of the Formulae I or II and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD l in mammals.Formula (I).
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Page/Page column 54
(2009/10/21)
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- SYNTHESIS OF 2-AMINO-3,5-DICHLOROBENZOIC ACID.
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A method has been devised for synthesis of 2-amino-3, 5-dichlorobenzoic acid by chlorination of 2-aminobenzoic acid with chlorine generated in the reaction of hydrochloric acid with hydrogen peroxide in presence of amides - formamide and N, N-dimethylformamide, with dielectric constants of 111. 5 and 37. 6 respectively at 20 degree . The influence of the chlorination temperature on the yield and quality of 2-amino-3,5-dichlorobenzoic acid was studied. Chlorination at temperatures above 55 degree increases the consumption of hydrogen peroxide by a factor of 1. 5-2. 0 and the reaction is accompanied by copious frothing and evolution of chlorine. Chlorination at 20-35 degree proceeds slowly and requires increase of the chlorination time to 30-40 h. The optimal temperature range for obtaining the maximum yield and highest quality of the product is 40-55 degree .
- Borodina
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p. 1087 - 1089
(2007/10/02)
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