- Synthesis of chloropolyfluoroarenes from polyfluoroarenethiols and PCl5
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Replacement of the thiol group in polyfluoroarenethiols with chlorine was performed by treating with PCl5 as chlorinating agent. By heating in ampules at 200-220°C polyfluoro- and polyfluorochloroarenethiols with PCl5 mono- and dichloropolyfluoroarenes and also 1,2,4-trifluorotrichlorobenzene were synthesized. Dichloropolyfluoroarenes contain chlorine atoms in ortho- and para-positions.
- Nikul'shin,Maksimov,Platonov
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p. 200 - 205
(2016/04/19)
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- Exploring new activating groups for reactive cysteine NCAs
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Due to its ability to reversibly crosslink proteins, cysteine has a unique role as an amino acid in nature. For controlled, asymmetric formation of disulfides from two thiols, one thiol needs to be activated. While few activating groups for cysteine have been proposed, they are usually not stable against amines making them unsuitable for solid phase peptide synthesis or amine initiated polymerization of α-amino acid-N-carboxy-anhydrides (NCAs). In this Letter we describe a series of new thiol activated cysteines, as well as their NCAs and explore the link between electron deficiency of the leaving group and control over NCA polymerization.
- Huesmann, David,Sch?fer, Olga,Braun, Lydia,Klinker, Kristina,Reuter, Thomas,Barz, Matthias
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p. 1138 - 1142
(2016/03/09)
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- THIOL-PROTECTED AMINO ACID DERIVATIVES AND USES THEREOF
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The present invention relates to thiol-protected amino acid derivatives of formulae (I) and (II), peptides and block-copolymers containing the compounds and methods for preparing same. The present invention also relates to core-shell particles comprising such thiol-protected block-copolymers and compositions thereof.
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Page/Page column 43
(2015/11/27)
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- Diaryl and heteroaryl sulfides: Synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents
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A mild protocol for the synthesis of diaryl and heteroaryl sulfides is described. In a one-pot procedure, thiols are converted to sulfenyl chlorides and reacted with arylzinc reagents. This method tolerates functional groups including aryl fluorides and chlorides, ketones, as well as N-heterocycles including pyrimidines, imidazoles, tetrazoles, and oxadiazoles. Two compounds synthesized by this method exhibited selective activity against the MCF-7 breast cancer cell line in the micromolar range.
- Yonova, Ivelina M.,Osborne, Charlotte A.,Morrissette, Naomi S.,Jarvo, Elizabeth R.
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p. 1947 - 1953
(2014/04/03)
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- Organofluorine sulfur-containing compounds: V. Joint pyrolysis with chlorine or bromine of polyfluoroarenethioles, polyfluorohetarenethioles, and their derivatives
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Joint pyrolysis with chlorine and bromine of polyfluoroarenethiols, -hetarenethiols, and their derivatives at 300-650°C furnished polyfluorocompounds containing chlorine and bromine. 2005 Pleiades Publishing, Inc.
- Platonov,Maksimov,Dvornikova,Nikul'shin
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p. 1647 - 1653
(2007/10/03)
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- An efficient preparative route to substituted alkyl benzenesulfenates, versatile reagents for site-selective sulfenylative cyclizations
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A versatile procedure for the synthesis of alkyl benzenesulfenates possessing varied patterns of nuclear substitution is described.
- Harring, Scott R.,Livinghouse, Tom
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p. 893 - 902
(2007/10/03)
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- REACTION OF TELLURIUM CHLORIDE PENTAFLUORIDE, TeF5Cl, WITH NITROGEN NUCLEOPHILES, PREPARATION AND CHARACTERIZATION OF THE ADDUCT (TeF4)2*NR2Cl, WHERE R=CH3, C2H5
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Reactions of TeF5Cl with the nitrogen nucleophiles LiN=C(CF3)2, ((CH3)3Si)2NH, and (CH3)3SiNR2, where R=CH3, C2H5, result in the reduction of the tellurium to Te(IV) and chlorination of the respective nucleophile.Analogous results are obtained in the reaction of TeF5Cl with (CH3)3SiCN, C6F5Li, and C6F5SLi.In the case of (CH3)3SiNR2, the new adducts (TeF4)2*NR2Cl are obtained in high yield.These compounds have been identified through their infrared, 1H, 19F, and 125Te NMR, and mass spectra as well as by elemental analysis.
- Thrasher, Joseph S.,Clark, Matthew,Morken, Peter A.
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p. 235 - 244
(2007/10/02)
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