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1H-Benzimidazole-5-carboxaldehyde,1-methyl-, also known as 1-methyl-1H-benzimidazole-5-carbaldehyde, is a chemical compound belonging to the class of organic compounds known as benzimidazoles. Benzimidazoles are characterized by a benzene ring fused to an imidazole ring. 1H-Benzimidazole-5-carboxaldehyde,1-methylcan be identified by its chemical formula C9H8N2O. The properties of 1H-Benzimidazole-5-carboxaldehyde,1-methyl-, such as molecular weight, melting and boiling points, solubility, and polarity, are influenced by specific physical and chemical conditions. Benzimidazoles, including 1-methyl-1H-benzimidazole-5-carboxaldehyde, are recognized in medicinal chemistry for their diverse pharmacological properties and are utilized in the synthesis of numerous therapeutic agents.

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  • 279226-70-9 Structure
  • Basic information

    1. Product Name: 1H-Benzimidazole-5-carboxaldehyde,1-methyl-
    2. Synonyms: 1H-Benzimidazole-5-carboxaldehyde,1-methyl-;1H-Benzimidazole-5-carboxaldehyde, 1-methyl- (9CI);1-Methylbenzimidazole-5-carboxaldehyde;1-Methyl-1H-benzimidazole-5-carboxaldehyde;1-Methyl-1H-1,3-benzodiazole-5-carbaldehyde
    3. CAS NO:279226-70-9
    4. Molecular Formula: C9H8N2O
    5. Molecular Weight: 160.17262
    6. EINECS: N/A
    7. Product Categories: ALDEHYDE;BENZIMIDAZOLE;AMINETERTIARY
    8. Mol File: 279226-70-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 336.9 °C at 760 mmHg
    3. Flash Point: 157.5 °C
    4. Appearance: /
    5. Density: 1.21 g/cm3
    6. Vapor Pressure: 0.000109mmHg at 25°C
    7. Refractive Index: 1.622
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 1H-Benzimidazole-5-carboxaldehyde,1-methyl-(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1H-Benzimidazole-5-carboxaldehyde,1-methyl-(279226-70-9)
    12. EPA Substance Registry System: 1H-Benzimidazole-5-carboxaldehyde,1-methyl-(279226-70-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 279226-70-9(Hazardous Substances Data)

279226-70-9 Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole-5-carboxaldehyde,1-methylis used as a key intermediate in the synthesis of various pharmaceutical compounds for its diverse pharmacological properties. It plays a crucial role in the development of therapeutic agents, contributing to the creation of new drugs with potential applications in treating various diseases and conditions.
Used in Medicinal Chemistry Research:
1H-Benzimidazole-5-carboxaldehyde,1-methylis employed as a research compound in medicinal chemistry, where it is studied for its potential interactions with biological targets. This helps in understanding its mechanism of action and exploring its potential as a lead compound for the development of new drugs.
Used in Drug Synthesis:
1H-Benzimidazole-5-carboxaldehyde,1-methylis used as a building block in the synthesis of a wide range of therapeutic agents. Its unique chemical structure allows for the formation of various derivatives, which can be further modified to enhance their pharmacological properties and improve their therapeutic potential.
Used in Drug Design:
1H-Benzimidazole-5-carboxaldehyde,1-methylis utilized in drug design to create novel compounds with improved pharmacological profiles. Its structural features can be incorporated into new drug candidates, potentially leading to the development of more effective and safer medications.

Check Digit Verification of cas no

The CAS Registry Mumber 279226-70-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,9,2,2 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 279226-70:
(8*2)+(7*7)+(6*9)+(5*2)+(4*2)+(3*6)+(2*7)+(1*0)=169
169 % 10 = 9
So 279226-70-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O/c1-11-6-10-8-4-7(5-12)2-3-9(8)11/h2-6H,1H3

279226-70-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-methylbenzimidazole-5-carbaldehyde

1.2 Other means of identification

Product number -
Other names 1-methyl-1H-benzoimidazole-5-carbaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:279226-70-9 SDS

279226-70-9Downstream Products

279226-70-9Relevant articles and documents

Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

álvarez, Raquel,Gajate, Consuelo,Puebla, Pilar,Mollinedo, Faustino,Medarde, Manuel,Peláez, Rafael

, p. 167 - 183 (2018/09/18)

Resistance to combretastatin A-4 is mediated by metabolic modification of the phenolic hydroxyl and ether groups of the 3-hydroxy-4-methoxyphenyl (B ring). Replacement of the B ring of combretastatin A-4 by a N-methyl-5-indolyl reduces tubulin polymerization inhibition (TPI) and cytotoxicity against human cancer cell lines but cyano, methoxycarbonyl, formyl, and hydroxyiminomethyl substitutions at the indole 3-position restores potent TPI and cytotoxicity against sensitive human cancer cell lines. These highly potent substituted derivatives displayed low nanomolar cytotoxicity against several human cancer cell lines due to tubulin inhibition, as shown by cell cycle analysis, confocal microscopy, and tubulin polymerization inhibitory activity studies, and promoted cell killing mediated by caspase-3 activation. Binding at the colchicine site was suggested by molecular modeling studies. Substituted combretastatins displayed higher potencies than the isomeric isocombretastatins and the highest potencies were achieved for the hydroxyiminomethyl (21) and cyano (23) groups, with TPI values in the submicromolar range and cytotoxicities in the nanomolar and subnanomolar range. Dose-response and time-course studies showed that drug concentrations as low as 1 nM (23) or 10 nM (21) led to a complete G2/M cell cycle arrest after 15 h treatment followed by a high apoptosis-like cell response after 48–72 h treatment. The P-glycoprotein antagonist verapamil increased 21 and 23 cytotoxicity to IC50 values of 10?10 M, and highly potentiated the cytotoxic activity in 100-fold of the CHO derivative (17), in A-549 human non-small cell lung cancer cells. The cyano substituted indolecombretastatin 23 is by itself highly potent against rather resistant HT-29 and A-549 cell lines. A 3,4,5-trimethoxyphenyl ring always afforded more potent derivatives than a 2,3,4-trimethoxyphenyl ring.

CALCIUM RECEPTOR MODULATING AGENTS

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Page 30, (2008/06/13)

The compounds of the invention are represented by the following general structure (I) or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

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