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106429-29-2

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106429-29-2 Usage

General Description

1H-Benzimidazol-5-ylmethanol, also known as 5-(Hydroxymethyl)-1H-benzimidazole, is an organic compound commonly used in the synthesis of novel chemical structures. Its IUPAC (International Union of Pure and Applied Chemistry) name is 1,3-dihydro-5-methyl-2H-benzimidazol-2-one. Although it does not have many widely recognized uses, its benzimidazole core is significant as it is seen in a variety of biologically active compounds. It has a molecular weight of around 162.174 g/mol and has the molecular formula C8H8N2O. It appears as a light yellow solid at room temperature. In terms of safety, it is considered to be a compound of low toxicity but irritant to the eyes and skin.

Check Digit Verification of cas no

The CAS Registry Mumber 106429-29-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,4,2 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 106429-29:
(8*1)+(7*0)+(6*6)+(5*4)+(4*2)+(3*9)+(2*2)+(1*9)=112
112 % 10 = 2
So 106429-29-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2O/c11-4-6-1-2-7-8(3-6)10-5-9-7/h1-3,5,11H,4H2,(H,9,10)

106429-29-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(Hydroxymethyl)-1H-benzimidazole

1.2 Other means of identification

Product number -
Other names 3H-benzimidazol-5-ylmethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106429-29-2 SDS

106429-29-2Relevant articles and documents

Substitution at the indole 3 position yields highly potent indolecombretastatins against human tumor cells

álvarez, Raquel,Gajate, Consuelo,Puebla, Pilar,Mollinedo, Faustino,Medarde, Manuel,Peláez, Rafael

, p. 167 - 183 (2018)

Resistance to combretastatin A-4 is mediated by metabolic modification of the phenolic hydroxyl and ether groups of the 3-hydroxy-4-methoxyphenyl (B ring). Replacement of the B ring of combretastatin A-4 by a N-methyl-5-indolyl reduces tubulin polymerization inhibition (TPI) and cytotoxicity against human cancer cell lines but cyano, methoxycarbonyl, formyl, and hydroxyiminomethyl substitutions at the indole 3-position restores potent TPI and cytotoxicity against sensitive human cancer cell lines. These highly potent substituted derivatives displayed low nanomolar cytotoxicity against several human cancer cell lines due to tubulin inhibition, as shown by cell cycle analysis, confocal microscopy, and tubulin polymerization inhibitory activity studies, and promoted cell killing mediated by caspase-3 activation. Binding at the colchicine site was suggested by molecular modeling studies. Substituted combretastatins displayed higher potencies than the isomeric isocombretastatins and the highest potencies were achieved for the hydroxyiminomethyl (21) and cyano (23) groups, with TPI values in the submicromolar range and cytotoxicities in the nanomolar and subnanomolar range. Dose-response and time-course studies showed that drug concentrations as low as 1 nM (23) or 10 nM (21) led to a complete G2/M cell cycle arrest after 15 h treatment followed by a high apoptosis-like cell response after 48–72 h treatment. The P-glycoprotein antagonist verapamil increased 21 and 23 cytotoxicity to IC50 values of 10?10 M, and highly potentiated the cytotoxic activity in 100-fold of the CHO derivative (17), in A-549 human non-small cell lung cancer cells. The cyano substituted indolecombretastatin 23 is by itself highly potent against rather resistant HT-29 and A-549 cell lines. A 3,4,5-trimethoxyphenyl ring always afforded more potent derivatives than a 2,3,4-trimethoxyphenyl ring.

Multi-target inhibitor acting on QC and GSK-3[beta]

-

, (2020/04/02)

The invention discloses a multi-target inhibitor acting on QC and GSK-3[beta], wherein the multi-target inhibitor has the structural general formula shown in the specification; according to active center crystal structures of target QC and GSK-3[beta] zymoprotein, with synthesis of multiple high-activity pharmacophores, the multi-target inhibitor capable of acting on QC and GSK-3[beta] at the sametime is prepared through skeletal transition and recombination design; the multi-target inhibitor is a high-activity molecule with multiple target points, the molecular structure diversity of a leaddrug is remarkably expanded, and research and development of innovative anti-AD drugs and AD diagnostic kits are actively promoted.

Substituted Pyran Derivatives

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Paragraph 0163; 0164, (2014/10/29)

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter system

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