28027-18-1

Basic information

• Product Name: 4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid
• Synonyms: 4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid;4-Hydroxy-8-Methoxyquinoline-3-caroboxylic acid
• CAS NO: 28027-18-1
• Molecular Formula: C₁₁H₉NO₄
• Molecular Weight: 219.19346
• EINECS: -0
• Mol File: 28027-18-1.mol

Chemical Properties

• Melting Point: 280 °C (decomp)
• Boiling Point: 407.1 °C at 760 mmHg
• Flash Point: 200 °C
• Appearance: /
• Density: 1.402 g/cm³
• Vapor Pressure: 2.34E-07mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• PKA: 0.73±0.30(Predicted)
• CAS DataBase Reference: 4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid(28027-18-1)
• EPA Substance Registry System: 4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid(28027-18-1)

Safety Data

• Hazardous Substances Data: 28027-18-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid is used as an antibiotic for the treatment of various bacterial infections due to its broad-spectrum action and effectiveness against a wide range of bacteria.
Used in Urinary Tract Infections:
In the medical field, 4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid is utilized as a therapeutic agent for urinary tract infections, where it targets and eliminates the causative bacteria, alleviating symptoms and promoting recovery.
Used in Respiratory Tract Infections:
This antibiotic is also employed in the treatment of respiratory tract infections, where it works to inhibit bacterial growth and reduce inflammation, facilitating a return to respiratory health.
Used in Skin and Soft Tissue Infections:
4-Hydroxy-8-methoxy-3-quinolinecarboxylic acid is used as a topical or systemic treatment for skin and soft tissue infections, helping to clear the infection and promote healing of the affected areas.

InChI:InChI=1/C11H9NO4/c1-16-8-4-2-3-6-9(8)12-5-7(10(6)13)11(14)15/h2-5H,1H3,(H,12,13)(H,14,15)

Upstream product

• 27568-04-3 Ethyl 4-hydroxy-8-methoxyquinoline-3-carboxylate 
• 104007-09-2 2-[(2-methoxyphenylamino)-methylene]-malonic acid diethyl ester 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 16778-21-5 4-chloro-8-methoxyquinoline 
• 27568-07-6 4-(3'-chlorophenylamino)-8-methoxyquinoline 
• 21269-34-1 4-hydroxy-8-methoxyquinoline 

Relevant articles and documents

Synthesis and anti-tumor activities of 4-anilinoquinoline derivatives

Twenty-two 7-fluoro (or 8-methoxy)-4-anilinoquinolines compounds were designed and synthesized as potentially potent and selective antitumor inhibitors. All the prepared compounds were evaluated for their in vitro antiproliferative activities against the HeLa and BGC823 cell lines. Ten compounds (1a-g; 2c; 2e and 2i) exhibited excellent antitumor activity superior to that of gefitinib. Among the ten compounds; seven (1a-c; 1e-1g and 2i) displayed excellent selectivity for BGC823 cells. In particular; 1f and 2i exhibited potent cytotoxic activities against HeLa cells and BGC823 cells with better IC50 values than gefitinib.