16778-21-5

Basic information

• Product Name: 4-Chloro-8-methoxyquinoline
• Synonyms: 4-CHLORO-8-METHOXYQUINOLINE;8-Methoxy-4-chloro quinoline;4-Chloro-8-Methoxyquinoline
• CAS NO: 16778-21-5
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.63
• EINECS: -0
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 16778-21-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 79-80 °C
• Boiling Point: 299.9 °C at 760 mmHg
• Flash Point: 135.2 °C
• Appearance: /
• Density: 1.267 g/cm³
• Vapor Pressure: 0.00207mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• PKA: 1.86±0.30(Predicted)
• CAS DataBase Reference: 4-Chloro-8-methoxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-8-methoxyquinoline(16778-21-5)
• EPA Substance Registry System: 4-Chloro-8-methoxyquinoline(16778-21-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 16778-21-5(Hazardous Substances Data)

Usage

Chemical Properties

yellow solid

Uses

Different sources of media describe the Uses of 16778-21-5 differently. You can refer to the following data:
1. A potent selective CRTh2(DP2) antagonist, as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.
2. A potent selective CRTh2(DP2) antagonist, as potential treatments for asthma, allergic rhinitis and other inflammatory diseases

InChI:InChI=1/C10H8ClNO/c1-13-9-4-2-3-7-8(11)5-6-12-10(7)9/h2-6H,1H3

Upstream product

• 27568-04-3 Ethyl 4-hydroxy-8-methoxyquinoline-3-carboxylate 
• 25165-68-8 5-[(2-methoxy-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 21269-34-1 4-hydroxy-8-methoxyquinoline 
• 104007-09-2 2-[(2-methoxyphenylamino)-methylene]-malonic acid diethyl ester 
• 90-04-0 2-methoxy-phenylamine 
• 28027-18-1 4-hydroxy-8-methoxyquinoline-3-carboxylic acid 

Downstream Products

• 131666-46-1 (8-Methoxy-quinolin-4-yl)-o-tolyl-amine 
• 63352-82-9 8-Methoxy-4-phenylquinoline 
• 7621-73-0 N⁴,N⁴-diethyl-N¹-(8-methoxy-[4]quinolyl)-1-methyl-butanediyldiamine 
• 27568-07-6 4-(3'-chlorophenylamino)-8-methoxyquinoline 
• 102660-26-4 4-(4-chloro-anilino)-7-piperidinomethyl-quinolin-8-ol 
• 145013-69-0 8-Methoxy-4-(4-methoxyphenyl)-5-nitroquinoline 
• 145013-67-8 8-Methoxy-5-nitro-4-phenylquinoline 
• 145297-33-2 4-(3,4-Dimethoxyphenyl)-8-methoxy-5-nitroquinoline 
• 145297-34-3 4-(4-Bromophenyl)-8-methoxy-5-nitroquinoline 
• 145297-36-5 8-Methoxy-7-nitro-4-phenylquinoline 

Relevant articles and documents

INHIBITORS FOR THE TREATMENT OF CANCER AND RELATED METHODS

Some embodiments of the invention include inventive compounds. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutica

SELECTIVE PFKFB4 INHIBITORS FOR THE TREATMENT OF CANCER

Methods and pharmaceutical compositions for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and the treatment of cancer are described.

Improved Syntheses of Some Monohloro- and Monobromo-8-quinolinols

Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz 1H-NMR spetra for the 12 possible monochloro