2812-31-9

Basic information

• Product Name: N(alpha),N(alpha)-Dimethylalanine
• Synonyms: N(alpha),N(alpha)-Dimethylalanine;N,N-dimethylalanine
• CAS NO: 2812-31-9
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.15
• Mol File: 2812-31-9.mol

Chemical Properties

• Melting Point: 184-185 °C
• Boiling Point: 179.9°Cat760mmHg
• Flash Point: 62.6°C
• Appearance: /
• Density: 1.033g/cm³
• Vapor Pressure: 0.431mmHg at 25°C
• Refractive Index: 1.45
• Storage Temp.: 2-8°C
• PKA: 2.34±0.11(Predicted)
• CAS DataBase Reference: N(alpha),N(alpha)-Dimethylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: N(alpha),N(alpha)-Dimethylalanine(2812-31-9)
• EPA Substance Registry System: N(alpha),N(alpha)-Dimethylalanine(2812-31-9)

Safety Data

• Hazardous Substances Data: 2812-31-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N(alpha),N(alpha)-Dimethylalanine is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of novel drugs with potential therapeutic applications, such as targeting specific receptors or enzymes in the body.
Used in Chemical Synthesis:
In the field of chemical synthesis, N(alpha),N(alpha)-Dimethylalanine serves as an important intermediate for the production of complex organic molecules. Its distinct properties enable the creation of new compounds with specific functionalities, which can be applied in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
N(alpha),N(alpha)-Dimethylalanine is utilized as a research tool in the study of protein structure, function, and interactions. Its unique properties allow scientists to investigate the effects of amino acid modifications on protein stability, folding, and binding affinity. This knowledge can be applied to the design of new proteins and peptides with improved or novel functions.
Used in Analytical Chemistry:
N(alpha),N(alpha)-Dimethylalanine can be employed as a reference compound or internal standard in various analytical techniques, such as chromatography and mass spectrometry. Its distinct properties make it suitable for comparing and quantifying other compounds in complex mixtures, contributing to the advancement of analytical methods and techniques.

InChI:InChI=1/C5H11NO2/c1-4(5(7)8)6(2)3/h4H,1-3H3,(H,7,8)

Downstream Products

• 42293-86-7 methyl (2S)-2-(dimethylamino)propanoate 
• 124731-69-7 (+)-N--L-prolyl>-L-phenylalanine methyl ester 
• 40916-65-2 (S)-2-(dimethylamino)-1-propanol 
• 38478-72-7 mauritine-A 
• 74492-06-1 (S)-alaphos 
• 1105044-29-8 (2S,2'S)-[(1S,2S)-1,2-diphenylethane-1,2-diyl] bis[2-(dimethylamino)propanoate] 
• 1105044-52-7 (2S,2'S)-N,N'-[(1S,2S)-1,2-diphenylethane-1,2-diyl] bis[2-(dimethylamino)propanamide] 
• 1150547-20-8 C₂₃H₃₄N₂O₄ 
• 1150547-22-0 C₂₅H₃₈N₂O₄ 
• 1150547-24-2 C₂₇H₄₂N₂O₄ 
• 1308331-91-0 diphenylmethyl (2S)-2-(dimethylamino)propanoate 
• 1308331-87-4 4-fluorobenzyl (2S)-2-(dimethylamino)propanoate 
• 1308331-85-2 4-methylbenzyl (2S)-2-(dimethylamino)propanoate 
• 1308331-88-5 2,4,6-trimethylbenzyl (2S)-2-(dimethylamino)propanoate 

Relevant articles and documents

Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba

Five Ib-type cyclopeptide alkaloids, jubanines F-J (1-5), and three known compounds, nummularine B (6), daechuine-S3 (7), and mucronine K (8) were isolated from the roots of Ziziphus jujuba. Their structures were fully characterized by spectroscopic analyses in combination with chemical derivatization. Compounds 1-3, and 6 were evaluated for their antiviral activity against the porcine epidemic diarrhea virus (PEDV). Compounds 2, 3, and 6 showed potent inhibitory effects on PEDV replication.

Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142

JBIR-141 (1) and JBIR-142 (2) were discovered as potent Foxo3a inhibitors that consist of three quite unique substructures, a 1-((dimethylamino)ethyl)-5-methyl-4,5-dihydrooxazole-4-carboxylic acid that is originated from Ala-Thr amino acid residues, a 3-acetoxy-4-amino-7-(hydroxy(nitroso)amino)-2,2-dimethylheptanoic acid, and an α-acyl tetramic acid fused with a 2-methylpropan-1-ol moiety. Their structures involving absolute configurations were determined by spectroscopic data, chemical degradation, anisotropy methods, and LC-MS analyses of diastereomeric derivatives. Compounds 1 and 2 exhibited specific inhibition against Foxo3a transcriptional activity with IC50 values of 23.1 and 166.2 nM, respectively.

Cyclopeptide alkaloids of Zizyphus xylopyra

14-Membered cyclopeptide alkaloids, franganine, frangufoline, amphibine-D and mauritine-A has been isolated from the whole plant of Zizyphus xylopyra and their structures established by spectral evidences. This is the first report of these alkaloids from Z. xylopyra.