40916-65-2

Basic information

• Product Name: 1-Propanol, 2-(dimethylamino)-, (S)-
• CAS NO: 40916-65-2
• Molecular Formula: C5H13NO
• Molecular Weight: 103.164
• Mol File: 40916-65-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-Propanol, 2-(dimethylamino)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 2-(dimethylamino)-, (S)-(40916-65-2)
• EPA Substance Registry System: 1-Propanol, 2-(dimethylamino)-, (S)-(40916-65-2)

Safety Data

• Hazardous Substances Data: 40916-65-2(Hazardous Substances Data)

Usage

Synonyms

S-(+)-2-(dimethylamino)-1-propanol

Physical state

Clear, colorless liquid

Functional groups

Tertiary amine, chiral amine

Uses

Chiral resolving agent in chromatography, reagent in organic synthesis, pharmaceutical intermediate, precursor for the synthesis of pharmaceutical products, corrosion inhibitor in metal alloys, anti-inflammatory agent in topical formulations.

Applications

Industrial and pharmaceutical.

Upstream product

• 152918-63-3 2-dimethylamino-3-methoxy-propionic acid 24-[8-acetoxy-6-(2-dimethylamino-propionyloxy)-2-hydroxy-11,11-dimethoxy-1,3,7,9-tetramethyl-undecyl]-10-hydroxy-14,20-dimethoxy-9,11,15,18-tetramethyl-2-oxo-oxacyclotetracosa-3,5,15,21-tetraen-8-yl ester 
• 50-00-0 formaldehyd 
• 2749-11-3 (S)-Alaninol 
• 14352-99-9 (S)-(-)-N,N-Dimethylalaninethylester 
• 2812-31-9 N,N-dimethyl-L-alanine 
• 124-40-3 dimethyl amine 
• 81408-31-3 (R)-1-[(4R,4'R,5R)-2,2,2',2'-tetramethyl-4,4′-bi(1,3-dioxolan)-5-yl]ethanol 
• 42293-86-7 methyl (2S)-2-(dimethylamino)propanoate 
• 90726-76-4 Butyl-D(+)-2-dimethylaminopropionat 

Downstream Products

• 15284-15-8 (+)-Methadone hydrochloride 
• 7576-08-1 (S)-(+)-2,2-diphenyl-4-dimethylaminopentanenitrile 
• 74492-06-1 (S)-alaphos 
• 15448-47-2 (R)-propylene oxide 
• 16088-62-3 (S)-Propylene oxide 

Relevant articles and documents

SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF

Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

4-ANILINO-QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS

A quinazoline derivative of the formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.

An Inversion of Chirality at a Chiral Micelle Surface

Two chiral quaternary ammonium bromide detergents S-1,2- and S-2,1-N-hexadecyl-N,N-dimethyl propanol bromide with the same S molecular configuration which are constituent isomers have been synthesised.They were used to prepare Amphiphillic Cholesteric Liquid Crystal (ACLC) samples where the molecular stereochemistry in respect to the micelle surface was inverted in respect to one another.Concomitant inversions in the sign of the optical rotation were found using the polarising microscope.Laser duffraction was used to determine the twists in these ACLC samples, which were found to be exceptionally small.The small twists were thought to be the result of the hydroxyl group in the chiral amphiphillic head group pushing the chiral centres apart. - Keywords: Amphiphillic liquid crystal, chiral micelle surface, cholesteric liquid crystal