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2-Chloro-6-(ethyloxy)quinoline-3-carbaldehyde is an organic compound with the molecular formula C13H10ClNO2. It is a derivative of quinoline, characterized by the presence of a chlorine atom and an ethyl ether group attached to the quinoline ring, along with a formyl group at the third position of the ring. 2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE is recognized for its potential applications in the synthesis of pharmaceuticals and agrochemicals, and it has been investigated for its antimicrobial and antiviral properties. Its unique structure and reactivity contribute to its value as an intermediate in the production of a variety of functionalized quinoline derivatives.

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  • 281208-98-8 Structure
  • Basic information

    1. Product Name: 2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE
    2. Synonyms: 2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE;AKOS AU36-M574;ASISCHEM D48942;2-CHLORO-6-ETHOXY-3-QUINOLINECARBOXALDEHYDE;2-CHLORO-6-ETHOXYQUINOLINE-3-CARBOXALDEHYDE;3-QUINOLINECARBOXALDEHYDE, 2-CHLORO-6-ETHOXY-;AKOS A1107-0007;OTAVA-BB 7118340023
    3. CAS NO:281208-98-8
    4. Molecular Formula: C12H10ClNO2
    5. Molecular Weight: 235.67
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 281208-98-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 384°C at 760 mmHg
    3. Flash Point: 186°C
    4. Appearance: /
    5. Density: 1.302g/cm3
    6. Vapor Pressure: 4.23E-06mmHg at 25°C
    7. Refractive Index: 1.639
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE(281208-98-8)
    12. EPA Substance Registry System: 2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE(281208-98-8)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22-36
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 281208-98-8(Hazardous Substances Data)

281208-98-8 Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-6-(ethyloxy)quinoline-3-carbaldehyde is utilized as a key building block in the development of pharmaceuticals. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 2-chloro-6-(ethyloxy)quinoline-3-carbaldehyde serves as an essential intermediate for the synthesis of new compounds designed to protect crops from pests and diseases.
Used as an Antimicrobial Agent:
2-Chloro-6-(ethyloxy)quinoline-3-carbaldehyde has been studied for its potential as an antimicrobial agent, indicating its use in combating various types of bacteria and other microorganisms.
Used as an Antiviral Agent:
2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE is also being explored for its antiviral properties, suggesting its potential use in the development of treatments for viral infections.
Used in the Synthesis of Functionalized Quinoline Derivatives:
Due to its reactivity and structural features, 2-chloro-6-(ethyloxy)quinoline-3-carbaldehyde is employed as an intermediate in the synthesis of a range of functionalized quinoline derivatives, which can have diverse applications in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 281208-98-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,1,2,0 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 281208-98:
(8*2)+(7*8)+(6*1)+(5*2)+(4*0)+(3*8)+(2*9)+(1*8)=138
138 % 10 = 8
So 281208-98-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H10ClNO2/c1-2-16-10-3-4-11-8(6-10)5-9(7-15)12(13)14-11/h3-7H,2H2,1H3

281208-98-8 Well-known Company Product Price

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  • Aldrich

  • (BBO000129)  2-Chloro-6-ethoxyquinoline-3-carboxaldehyde  AldrichCPR

  • 281208-98-8

  • BBO000129-1G

  • 2,255.76CNY

  • Detail

281208-98-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-6-ethoxyquinoline-3-carbaldehyde

1.2 Other means of identification

Product number -
Other names 3-Quinolinecarboxaldehyde,2-chloro-6-ethoxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:281208-98-8 SDS

281208-98-8Relevant articles and documents

Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies

Nasr, Tamer,Bondock, Samir,Rashed, Hassan M.,Fayad, Walid,Youns, Mahmoud,Sakr, Tamer M.

, p. 723 - 739 (2018/04/26)

The current work presents the synthesis and biological evaluation of new series of coumarin hydrazide-hydrazone derivatives that showed in vitro broad spectrum antitumor activities against resistant pancreatic carcinoma (Panc-1), hepatocellular carcinoma (HepG2) and leukemia (CCRF) cell lines using doxorubicin as reference standard. Bromocoumarin hydrazide-hydrazone derivative (BCHHD) 11b showed excellent anticancer activity against all tested cancer cell lines. Enzyme assays showed that BCHHD 11b induced apoptosis due to activation of caspases 3/7. Moreover, 11b inhibited GST and CYP3A4 in a dose dependent manner and the induced cell death could be attributed to metabolic inhibition. Moreover, 11b microarray analysis showed significant up- and down-regulation of many genes in the treated cells related to apoptosis, cell cycle, tumor growth and suppressor genes. All of the above presents BCHHD 11b as a potent anticancer agent able to overcome drug resistance. In addition, compound 11b was able to serve as a chemical carrier for 99mTc and the in vivo biodistribution study of 99mTc-11b complex revealed a remarkable targeting ability of 99mTc into solid tumor showing that 99mTc-11b might be used as a promising radiopharmaceutical imaging agent for cancer.

SUBSTITUTED 6,7-DIALKOXY-3-ISOQUINOLINOL DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE10A)

-

, (2012/09/05)

The invention relates to compounds of the formula wherein R′, R1, through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.

Synthesis of New dihydropyrimidinones catalysed by dicationic ionic Liquid

Jawale, Dhanaji V.,Pratap, Umesh R.,Mulay, Aparna A.,Mali, Jyotirling R.,Mane, Ramrao A.

scheme or table, p. 645 - 655 (2012/07/03)

A convenient multi step synthetic protocol for new dihydropyrimidinones bearing quinolynyl methoxy phenyl moiety has been developed from 2-chloro-3-formyl quinolines. The last step is one-pot Biginelli reaction of multicomponents, 4-((2-chloroquinolin-3-yl) methoxy) benzaldehydes, ethyl acetoacetate and urea mediated and catalysed by dicationic ionic liquid (3-methyl-1-[3-(methyl-1H-imidazolium-1-yl) propyl]- 1H-imidazolium dibromide (C3 [min]2 2 [Br-] )). Simple work-up procedures and moderate to good yields of the pyrimidinones and the intermediates are the merits of the route. Indian Academy of Sciences.

NON-PEPTIDE GLP-1 AGONISTS

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Page/Page column 51, (2010/02/13)

Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an ac

NOVEL 2-SUBSTITUTED CYCLIC AMINES AS CALCIUM SENSING RECEPTOR MODULATORS

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Page 83 - 84, (2010/02/08)

The present invention relates to modulators of the calcium sensing receptor having the formula I (I) wherein Ar, X, n, R, R, R, and Q are as defined herein.

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