333408-52-9

Usage

InChI:InChI=1/C12H12ClNO2/c1-2-16-10-3-4-11-8(6-10)5-9(7-15)12(13)14-11/h3-6,15H,2,7H2,1H3

Upstream product

• 281208-98-8 2-chloro-6-ethoxyquinoline-3-carbaldehyde 
• 62-44-2 4-ethoxyacetanilide 

Downstream Products

• 1391868-25-9 ethyl 4-(4-((2-chloro-6-ethoxyquinolin-3-yl)methoxy)phenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1334446-25-1 (2-chloro-6-ethoxyquinolin-3-yl)methyl 4-methylbenzenesulfonate 
• 1334446-41-1 (Z)-5-([4-(2-chloro-6-ethoxyquinolin-3-yl)methoxy]benzylidine)thiazolidine-2,4-dione 
• 1334446-33-1 4-((2-chloro-6-ethoxyquinolin-3-yl)methoxy)benzaldehyde 

Relevant academic research and scientific papers

Synthesis of New dihydropyrimidinones catalysed by dicationic ionic Liquid

A convenient multi step synthetic protocol for new dihydropyrimidinones bearing quinolynyl methoxy phenyl moiety has been developed from 2-chloro-3-formyl quinolines. The last step is one-pot Biginelli reaction of multicomponents, 4-((2-chloroquinolin-3-yl) methoxy) benzaldehydes, ethyl acetoacetate and urea mediated and catalysed by dicationic ionic liquid (3-methyl-1-[3-(methyl-1H-imidazolium-1-yl) propyl]- 1H-imidazolium dibromide (C3 [min]2 2 [Br-] )). Simple work-up procedures and moderate to good yields of the pyrimidinones and the intermediates are the merits of the route. Indian Academy of Sciences.

Synthetic Route for New (Z)-5-[4-(2-Chloroquinolin-3-yl) Methoxy]benzylidinethiazolidine-2,4-diones

Synthetic route has been developed for the synthesis of new (Z)-5-[4-(2-chloroquinolin-3-yl) methoxy]benzylidinethiazolidine-2,4-diones (6a-h) starting from 2-chloro-3-hydroxymethyl quinolines (2a-h). The hydroxy methyl quinolines on tosylation yielded (3a-h). Condensation of the tosyl intermediates with 4-hydroxy benzaldehydes has been carried in DMF in presence of K2CO3 and obtained 4-quinolinyl methoxy benzaldehydes (4a-h). Conveniently Knoevenagel condensation of quinolinyl methoxy benzaldehydes (4a-h) and 2, 4-thiazolidinedione (5) has been carried in PEG-400 in presence of L-proline and obtained better yields of the titled compounds (6a-h).

Simple and efficient synthesis of new O,O-diethyl phosphorothioates

A simple and highly effective method was developed for the synthesis of new O,O-diethyl phosphorothioates from O,O-diethyl phosphorochloridothioate and 2-chloroquinolin-3-ylmethanol derivatives in the presence of sodium hydroxide.