- Direct oxidative conversion of benzylhalides, -amines, -alcohols, and arylaldehydes to nitriles with trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane activated by NH4Br
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A simple and efficient oxidative conversion of benzyl derivatives of halides, amines, alcohols, and aldehydes into corresponding nitriles is described using trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane in the presence of NH4Br. The reactions proceeded smoothly at room temperature to afford the products in high-to-excellent yields. Graphical Abstract: [Figure not available: see fulltext.]
- Azarifar, Davood,Najminejad, Zohreh
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p. 107 - 111
(2015/01/30)
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- Palladium-catalyzed highly selective ortho-halogenation (I, Br, Cl) of arylnitriles via sp2 C-H bond activation using cyano as directing group
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A palladium-catalyzed ortho-halogenation (I, Br, Cl) of arylnitrile is described. The optimal reaction conditions were identified after examining various factors such as catalyst, additive, solvent, and reaction temperature. Using cyano as the directing group, the halogenation reaction gave good to excellent yields. The method is compatible to the arylnitriles with either electron-withdrawing or electron-donating groups. The reaction is available to the substrate in at least gram scale. The present method was successfully applied to the synthesis of the precursors of paucifloral F and isopaucifloral F.
- Du, Bingnan,Jiang, Xiaoqing,Sun, Peipei
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p. 2786 - 2791
(2013/04/24)
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- Synthesis of aryl nitriles using the stable aryl diazonium silica sulfates
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An efficient method for preparation of aryl nitriles is reported using Cu(I) to catalyse the reaction of aryl diazonium silica sulfates with sodium cyanide under mild conditions at room temperature in water. This method has the advantages of high yields,
- Habibi, Davood,Heydari, Somayyeh,Nasrollahzadeh, Mahmoud
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p. 573 - 574,2
(2020/09/16)
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- 3-Chloro-4-cyanophenyl 4'-substituted benzoates
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Disclosed are compounds of the formula: STR1 wherein R is an alkyl group having 1 to 8 carbon atoms and X is a dioxane, cyclohexane, or benzene ring. The compounds of the invention are suitable as liquid crystal materials in electrooptical displays. Specifically, when added to nematic liquid crystals, these compounds provide an increase in the positive dielectric anisotropy of the liquid crystal composition.
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- Anthelmintic 1-(substituted phenyl)-3-alkanimidoyl ureas
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The compounds of this invention are novel imidoylureas having anthelmintic activity and imidoylthioureas having antifertility activity. They are prepared by the reaction of appropriate amidines with appropriate isocyanates or isothiocyanates.
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