28342-75-8

Basic information

• Product Name: 1,5-DIBROMO-2,4-DIFLUOROBENZENE
• Synonyms: 1,5-DIBROMO-2,4-DIFLUOROBENZENE;1,5-Dibromo-2,4-difluorobenzene 98%;1,3-DibroMo-4,6-difluorobenzene;2,4-Difluoro-1,5-dibromobenzene;1.3-Dibrom-4.6-difluorben;1.3-Dibrom-4.6-difluorbenzol
• CAS NO: 28342-75-8
• Molecular Formula: C₆H₂Br₂F₂
• Molecular Weight: 271.886
• Product Categories: Bromine Compounds;Fluorine Compounds
• Mol File: 28342-75-8.mol

Chemical Properties

• Melting Point: 29.0 to 33.0 °C
• Boiling Point: 100℃ (25 Torr)
• Flash Point: 75.588 °C
• Appearance: /
• Density: 2.088 g/cm³
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1,5-DIBROMO-2,4-DIFLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-DIBROMO-2,4-DIFLUOROBENZENE(28342-75-8)
• EPA Substance Registry System: 1,5-DIBROMO-2,4-DIFLUOROBENZENE(28342-75-8)

Safety Data

• Hazardous Substances Data: 28342-75-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,5-Dibromo-2,4-difluorobenzene is used as a building block for the production of pharmaceuticals, leveraging its unique chemical properties to create a wide range of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 1,5-Dibromo-2,4-difluorobenzene serves as a key intermediate in the synthesis of various agrochemicals, contributing to the development of effective crop protection agents.
Used in Organic Synthesis:
1,5-Dibromo-2,4-difluorobenzene is utilized as an intermediate in the synthesis of a variety of organic compounds, including dyes and polymers, due to its reactive nature and ability to participate in multiple types of chemical reactions.
Used in Material Science:
1,5-Dibromo-2,4-difluorobenzene is also employed in the development of new materials, where its unique properties can be harnessed to create innovative products with specific characteristics for various applications.
Safety Note:
Given its moderately toxic nature, 1,5-Dibromo-2,4-difluorobenzene requires careful handling and disposal to ensure the safety of both individuals and the environment.

Upstream product

• 679836-60-3 1,5-dibromo-2,4-difluoro-3-iodobenzene 
• 348-57-2 2,4-difluorobromobenzene 

Downstream Products

• 679836-60-3 1,5-dibromo-2,4-difluoro-3-iodobenzene 
• 355423-48-2 2,4-difluoro-5-bromophenol 
• 1136948-11-2 2,2'-(4,6-difluoro-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) 
• 1529811-72-0 n-butyl 3,5-dibromo-2,6-difluorobenzoate 
• 1529811-73-1 n-butyl 2,6-difluoro-3,5-di(2-pyridyl)benzoate 
• 959049-37-7 C₁₅H₂₀F₂O₂ 
• 28314-84-3 3,5-dibromo-2,6-difluorobenzoic acid 
• 1609563-32-7 1,3-difluoro-4,6-di(3-pyridylethynyl)benzene 
• 1609563-34-9 1,3-difluoro-4,6-di(p-trifluoromethylphenylethynyl)benzene 
• 1260879-25-1 5-bromo-2,4-difluorobenzonitrile 
• 1436919-37-7 1,5-bis(n-butylethynyl)-2,4-bis(p-tolyloxy)benzene 
• 1436919-34-4 1,5-bis(n-butylethynyl)-2,4-difluorobenzene 
• 1436919-36-6 1,5-bis(tert-butylethynyl)-2,4-bis(p-tolyloxy)benzene 
• 1436919-33-3 1,5-bis(tert-butylethynyl)-2,4-difluorobenzene 

Relevant articles and documents

The effect of frontier orbital distribution of the core structure on the photophysics and device performances of thermally activated delayed fluorescence emitters

The effect of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) distribution of the core structure on the thermally activated delayed fluorescence (TADF) behavior of the TADF emitters was investigated. Dibenzofuran was used as the core structure of the TADF materials, and its 2 and 3 positions were substituted with a donor and an acceptor. Two TADF emitters with the donor and acceptor positions exchanged with each other were synthesized and suggested that the substitution of the donor at the LUMO dominant position and the acceptor at the HOMO dominant position is beneficial to improve the efficiency of the TADF OLEDs. It was described that the substitution positions of the donor and acceptor to the core structure should be managed to increase the quantum efficiency of the TADF devices by enlarged orbital overlap.

Highly efficient and color tunable thermally activated delayed fluorescent emitters using a "twin emitter" molecular design

High efficiency and color tuning of thermally activated delayed fluorescent emitters were achieved at the same time by designing emitters with a twin emitter molecular design. The control of the interconnect position between two emitters could manage the

Heteroleptic Ir(III) phosphors with bis-tridentate chelating architecture for high efficiency OLEDs

A bis-tridentate iridium complex represented by a formula (I): where R3 to R8, R21 to R23, R9, R10, X1, X2, and X3 are as defined in the specification.

4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: (I) wherein R1 and R2 are independently hydrogen, or -CH3; or R1 and R2 can join together in a ring by adding -(CH2)4-; R3 is hydrogen or C1-C3 al-kyl; Y and Z are independently a C6-C10- aryl group or a 5-10 membered heterocyclic group which can be further substituted with from 0-3 substituents selected from the group of halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino, halo C1-4 alkyl, CN, C1-C6, alkyl or cycloalkyl, C1-C6 alkoxy, -C=OC1-4 alkyl, -SO2C1-4 alkyl, and C2-C4 alkynyl; A is selected from the group of phenyl, ben-zyl, oxazolyl, thiazolyl, isoxazolyl, imidazolyl, pyrazolyl, pyridyl, pyrimidinyl, and pyrazinyl groups which can be further substituted with from 0-3 substituents selected from the group of halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino, haloC1-4 alkyl, hydroxyC1-6 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; L is -NHCO-, or is a single bond; and L and Z to-gether can be absent

COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: wherein R1, R2, R3, R4, R5, and R6 are independently hydrogen, C1-C6 alkyl or C1-C6 cycloalkyl; Y and Z are independently a C6-C10- aryl group or a 5-10 membered heterocyclic group, wherein each Y and Z group can be optionally substituted with from 0-3 substituents selected from halogen, amino, C1-4alkylamino, C1-4dialkylamino, haloC1-4 alkyl, OH, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; L is either a bond or is -NHCO-; L and Z together can be absent; and m is 1, 2 or 3.

Luminescent iridium(III) complexes with N^C^N- coordinated terdentate ligands: Dual tuning of the emission energy and application to organic light-emitting devices

A family of complexes (1a-3a and 1b-3b) was prepared, having the structure Ir(N^C^N)(N^C)Cl. Here, N^C ^N represents a terdentate, cyclometallating ligand derived from 1,3-di(2-pyridyl)benzene incorporating CH3 (1a,b), F (2a,b), or CF3 (3a,b) substituents at the 4 and 6 positions of the benzene ring, and N^C is 2-phenylpyridine (series a) or 2-(2,4-difluorophenyl) pyridine (series b). The complexes are formed using a stepwise procedure that relies on the initial introduction of the terdentate ligand to form a dichloro-bridged iridium dimer, followed by cleavage with the N^C ligand. 1H NMR spectroscopy reveals that the isomer that is exclusively formed in each case is that in which the pyridyl ring of the N ^C ligand is trans to the cyclometallating aryl ring of the N ^C^N ligand. This conclusion is unequivocally confirmed by X-ray diffraction analysis for two of the complexes (1b and 3a). All of the complexes are highly luminescent in degassed solution at room temperature, emitting in the green (1a,b), blue-green (2a,b), and orange-red (3a,b) regions. The bidentate ligand offers independent fine-tuning of the emission energy: for each pair, the "b" complex is blue-shifted relative to the analogous "a" complex. These trends in the excited-state energies are rationalized in terms of the relative magnitudes of the effects of the substituents on the highest occupied and lowest unoccupied orbitals, convincingly supported by time-dependent density functional theory (TD-DFT) calculations. Luminescence quantum yields are high, up to 0.7 in solution and close to unity in a PMMA matrix for the green-emitting complexes. Organic light emitting devices (OLEDs) employing this family of complexes as phosphorescent emitters have been prepared. They display high efficiencies, at least comparable, and in some cases superior, to similar devices using the well-known tris-bidentate complexes such as fac-Ir(ppy)3. The combination of terdentate and bidentate ligands is seen to offer a versatile approach to tuning of the photophysical properties of iridium-based emitters for such applications.

BACE INHIBITORS

The present invention provides BACE inhibitors of Formula I: methods for their use, intermediates, and methods for their preparation.

METAL COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME

Provided are an organic electroluminescence device whose wavelength of light emission is short and which can emit blue light having a high color purity, and a metal complex compound for realizing the device. The metal complex compound is of a specific str

PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME

The present invention provides a novel compound having an excellent JNK inhibitory effect. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 designates -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb and Rc each independently designate a hydrogen atom, a halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group or the like; Cy designates a 5- or 6-membered heteroaryl; and V each independently designate the formula -L-X-Y (wherein L designates a single bond, an optionally substituted C1-6 alkylene group or the like; X designates a single bond or the formula -A- (wherein A designates NR2, O, CO, S, SO or SO2) and so on; and Y designates a hydrogen atom, a halogen atom, nitro group or the like).

Azo Group-Assisted Nucleophilic Aromatic Substitutions in Haloarene Derivatives: Preparation of Substituted 1-Iodo-2,6-bispropylthiobenzenes

Aryldiazo substituents were usfed in nucleophilic aromatic substitution reactions of halogens. The Ph-N=N- group activates ortho fluorine atoms toward alkylthiolation under mild conditions. In contrast, the Me2N-C6H4-N=N- group has virtually no activation effect in nucleophilic aromatic substitution, and serves as a "neutral" mask for the amino group. The Ph-N=N- group was efficiently introduced by diazo coupling of aryllithium with dry PhN2(1+)BF4(1-) salt.