1,5-Dibromo-2,4-difluorobenzene

Base Information

• Chemical Name: 1,5-Dibromo-2,4-difluorobenzene
• CAS No.: 28342-75-8
• Molecular Formula: C6H2Br2F2
• Molecular Weight: 271.887
• Hs Code.: 2903999090
• European Community (EC) Number: 639-298-8
• DSSTox Substance ID: DTXSID80441851
• Nikkaji Number: J690.949C
• Wikidata: Q82258827
• Mol file: 28342-75-8.mol

Synonyms:1,5-Dibromo-2,4-difluorobenzene;28342-75-8;2,4-Dibromo-1,5-difluorobenzene;1,3-dibromo-4,6-difluorobenzene;Benzene, 1,5-dibromo-2,4-difluoro-;MFCD08458122;SCHEMBL502648;DTXSID80441851;PPUZKAPOPPRMFE-UHFFFAOYSA-N;1,3 dibromo-4,6-difluorobenzene;1,5-Difluoro-2,4-dibromobenzene;AMY30263;AKOS015834804;AS-19713;SY022998;CS-0157855;D5259;FT-0767119;EN300-194137;A850334;J-504015

Chemical Property of 1,5-Dibromo-2,4-difluorobenzene

Chemical Property:

• Melting Point: 29.0 to 33.0 °C
• Boiling Point: 201.373 °C at 760 mmHg
• Flash Point: 75.588 °C
• PSA: 0.00000
• Density: 2.088 g/cm³
• LogP: 3.48980
• Storage Temp.: Room temperature.
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 271.84708
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,5-Dibromo-2,4-difluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CC(=C1F)Br)Br)F

Technology Process of 1,5-Dibromo-2,4-difluorobenzene

There total 2 articles about 1,5-Dibromo-2,4-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,4-difluorobromobenzene (348-57-2) → 1,5-dibromo-2,4-difluorobenzene (28342-75-8)

Guidance literature:

With sulfuric acid; tribromide; iron;

DOI:10.1021/jo0302399

Reference yield:

1,5-dibromo-2,4-difluoro-3-iodobenzene (679836-60-3) → 1,5-dibromo-2,4-difluorobenzene (28342-75-8)

Guidance literature:

With 1-thiopropane; sodium hydride; In dimethyl sulfoxide; at 90 ℃; for 48h;

DOI:10.1016/S0022-1139(03)00172-6

Reference yield: 90.0%

1,5-dibromo-2,4-difluorobenzene (28342-75-8) + trimethylsilylacetylene (1066-54-2) → ((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) (1379822-10-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 80 ℃; for 18h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol5010627

upstream raw materials:

2,4-difluorobromobenzene

1,5-dibromo-2,4-difluoro-3-iodobenzene

Downstream raw materials:

1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-5-bromo-2,4-difluorobenzene

1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-bromo-2,4-difluorobenzene

4,6-difluoro-isophthalonitrile

1,5-dibromo-2,4-difluoro-3-iodobenzene

Refernces

• 1、 Kim, Mounggon,Jeon, Sang Kyu,Hwang, Seok-Ho,Lee, Sang-Shin,Yu, Eunsun,Lee, Jun Yeob. "Highly efficient and color tunable thermally activated delayed fluorescent emitters using a "twin emitter" molecular design". . p. 339 - 342. Retrieved 2016/01/09.
• 2、 -. "4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION". Page/Page column 26; 27. . Retrieved 2014/07/08.