28448-11-5

Basic information

• Product Name: 2-AMINO-4-METHYL-QUINOLINE-3-CARBONITRILE
• Synonyms: 2-AMINO-4-METHYL-QUINOLINE-3-CARBONITRILE;2-Amino-4-methyl-quinoline-3-carbonitrile ,98%
• CAS NO: 28448-11-5
• Molecular Formula: C₁₁H₉N₃
• Molecular Weight: 183.21
• Mol File: 28448-11-5.mol

Chemical Properties

• Boiling Point: 399.1 °C at 760 mmHg
• Flash Point: 195.2 °C
• Appearance: /
• Density: 1.24 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-AMINO-4-METHYL-QUINOLINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-METHYL-QUINOLINE-3-CARBONITRILE(28448-11-5)
• EPA Substance Registry System: 2-AMINO-4-METHYL-QUINOLINE-3-CARBONITRILE(28448-11-5)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 28448-11-5(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

Upstream product

• 551-93-9 2-aminoacetophenone 
• 109-77-3 malononitrile 

Downstream Products

• 383866-53-3 5-methyl-2-phenyl-1,3-oxazino[4,5-b]quinoline-4-one 
• 383866-51-1 5-methyl-2-phenyl-2-deoxo-5-deazaalloxazine 

Relevant articles and documents

Synthesis, characterization and reactions of 2-deoxo-5-deazaalloxazines

5-Deazaflavins and their homologues have been known as potential riboflavin antagonists, bioreductives, and compounds with potent antitumor activity 2-Amino-4-methylquinoline-3-carbonitrile (2) was prepared as unreported starting material for several interesting 2-deoxo-5-deazalloxazine derivatives. Cyclization of 2 using formamide afforded the 2,4-deoxo-5-dea-zaalloxazine derivative 7, which was subjected to deamination with nitrous acid to give the 2-deoxo-5-deazaalloxazine (8). The compound 8 was also obtained via 13 by treating the latter with refluxing formic acid or formamide and used as a recursor for synthesis of several 2-deoxo-5-deazaalloxazines 18, 19 , 20, 21 and 22. The pharmacological and biological properties of these compounds are still under investigation. Copyright

Methylheteroaromatic Carbonitriles as Building Blocks for the Synthesis of Condensed Heteroaromatics: A Novel Syntheses of Benzopyranopyridines, Naphthopyranopyridines, Pyridoquinolines and Other New Condensed Pyridines

The alkylheteroatomic carbonitriles 1a-b and 2 are condensed with dimethylformamide dimethylacetal to yield the (E)-dimethylaminoethylene derivatives 4a-b and 5.The reaction of 3 with the same reagent afforded the amidine derivative 7 in addition to the (E)-dimethylaminoethylene 6.Compounds 4a-b and 5-6 were converted into condensed pyridone derivatives on reflux in acetic acid/hydrochloric acid mixture.The reaction of 6 with acetic anhydride afforded the tetracyclo derivative 14.Compounds 4a,b were converted into the (E)-anilinoethylene derivatives 4c,d bytreatment with aniline.These compounds (4e,d) cyclised readily to the condensed N-phenylpyridones 8c,d on reflux in DMF, while compound 5 afforded 9b directly under the same conditions.Compound 7 reacted with sulfur to give the polycyclic 16.