284664-96-6

Basic information

• Product Name: L-LYSINE-4,4,5,5-D4 HCL
• Synonyms: L-Lysine-d4 HCl;BVHLGVCQOALMSV-UGJIAQRQSA-N
• CAS NO: 284664-96-6
• Molecular Formula: H2NCH2(CD2)2CH2CH(NH2)COOH?HCl
• Product Categories: Amines, Amino Acids & Derivatives, Isotope Labelled Compounds
• Mol File: 284664-96-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-LYSINE-4,4,5,5-D4 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: L-LYSINE-4,4,5,5-D4 HCL(284664-96-6)
• EPA Substance Registry System: L-LYSINE-4,4,5,5-D4 HCL(284664-96-6)

Safety Data

• Hazardous Substances Data: 284664-96-6(Hazardous Substances Data)

Usage

Uses

Used in Biomedical Research:
L-LYSINE-4,4,5,5-D4 HCL is used as a labeling agent for the analysis of human bone marrow mesenchymal stem cells. The incorporation of deuterium atoms in the L-Lysine molecule allows for the differentiation and tracking of these cells in various experimental setups, providing valuable insights into their behavior, function, and potential therapeutic applications.
Used in Cell Biology:
In the field of cell biology, L-LYSINE-4,4,5,5-D4 HCL serves as a valuable tool for studying the metabolism and incorporation of amino acids into proteins within human bone marrow mesenchymal stem cells. The labeled amino acid can be used to monitor protein synthesis, turnover, and other cellular processes, contributing to a better understanding of cellular mechanisms and potential therapeutic targets.
Used in Drug Development:
The unique properties of L-LYSINE-4,4,5,5-D4 HCL make it a potential candidate for drug development, particularly in the context of targeted therapies and personalized medicine. The labeled amino acid can be used to study the interactions between stem cells and potential therapeutic agents, helping to identify novel drug candidates and optimize their efficacy and safety profiles.
Used in Analytical Chemistry:
L-LYSINE-4,4,5,5-D4 HCL can be employed in various analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, to study the structure, dynamics, and interactions of biomolecules. The presence of deuterium atoms in the molecule enhances the sensitivity and resolution of these analytical methods, enabling more accurate and detailed characterization of biological systems.

Upstream product

• 183069-80-9 [3,3,4,4,5,5-2H6]-ε-caprolactam 

Relevant articles and documents

Stereoselective synthesis of d4-(S)-Lysine from (S)-Serine

Tetradeuterated (S)-lysine can easily be obtained from protected (S)-serine in a few steps including a Cu-mediated cross coupling and subsequent platinum-catalysed deuteration.

Synthesis of - and Lysines

Starting from readily available cyclohexanone (1), synthesis of the title - and lysines (11) and (18) is described.Although direct incorporation of an amino or phthalimide group into the 2-bromohexanoic acid (5), which was derived from 1 in five steps. leading to 11 was unsuccessful due to hydrogen-deuterium scrambling, compound (11) was obtained in 86percent deuterium content via incorporation of an azido group and subsequent hydrogenation.Furthermore, compound (18) having 99percent deuterium content could be prepared by acid-catalysed deuterium exchange of 1 as a key-step.