284672-81-7Relevant articles and documents
Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
B?urle, Stefan,Nagel, Jens,Peters, Olaf,Br?uer, Nico,Ter Laak, Antonius,Preusse, Cornelia,Rottmann, Antje,Heldmann, Dieter,Bothe, Ulrich,Blume, Thorsten,Zorn, Ludwig,Walter, Daryl,Zollner, Thomas M.,Steinmeyer, Andreas,Langer, Gernot
, p. 2541 - 2563 (2019/04/03)
The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes - the latter being frequently associated with severe, acute, and chronic pelvic pain. T
EP4 antagonist dihydrobenzo imidazolecarboxylic deriv. new
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Paragraph 0161, (2016/10/08)
The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected w
Novel benzimidazole derivatives as EP4 ligands
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Paragraph 0494; 0495; 0496, (2016/11/17)
The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the E
NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 LIGANDS
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Page/Page column 48-49, (2017/01/26)
The present invention relates to novel benzimidazole derivatives of the general formula (I), to processes for their preparation and to their use for preparing pharmaceutical compositions for the treatment of disorders and indications associated with the E
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b
Semple, Graeme,Skinner, Philip J.,Cherrier, Martin C.,Webb, Peter J.,Sage, Carleton R.,Tamura, Susan Y.,Chen, Ruoping,Richman, Jeremy G.,Connolly, Daniel T.
, p. 1227 - 1230 (2007/10/03)
1-Substituted benzotriazole carboxylic acids have been identified as the first reported examples of selective small-molecule agonists of the human orphan G-protein-coupled receptor GPR109b (HM74), a low-affinity receptor for the HDL-raising drug niacin. N