The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
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(2021/03/19)
Photochemistry of 3- and 5-phenylisothiazoles. Competing phototransposition pathways
5-Phenylisothiazole undergoes phototransposition via the electrocyclic ring closure-heteroatom migration pathway and by the N2-C3 interchange reaction pathway. The latter route is enhanced by the addition of triethylamine (TEA) to the reaction medium and by increasing the polarity of the solvent. In addition to phototransposition, 5-phenylisothiazole also undergoes photocleavage to 2-cyano-1-phenylethenethiol which was trapped by reaction with benzyl bromide to yield 2-cyano-1-phenylethen-1-ylbenzyl thioether. 3-Phenylisothiazole also phototransposes by both reaction pathways, but the product distribution is not affected by the addition of TEA or by changing the solvent polarity.
Pavlik, James W.,Tongcharoensirikul, Pakamas
p. 3626 - 3631
(2007/10/03)
Penicillins from 3- and 5-phenylisothiazole-4-carboxylic acids and alkoxy derivatives.
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Micetich,Raap
p. 159 - 160
(2007/10/10)
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