284680-72-4

Upstream product

• 98-86-2 acetophenone 
• 33603-87-1 (Z)-3-chloro-3-phenyl-2-propenal 
• 1075-21-4 5-phenylisothiazole 
• 90792-75-9 3-amino-4-bromo-5-phenylisothiazole 

Downstream Products

• 284680-73-5 4-deuterio-5-phenylisothiazole 
• 533937-68-7 5-phenyl-isothiazole-4-carbonitrile 

Relevant academic research and scientific papers

MTA-Cooperative PRMT5 Inhibitors

The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Photochemistry of 3- and 5-phenylisothiazoles. Competing phototransposition pathways

5-Phenylisothiazole undergoes phototransposition via the electrocyclic ring closure-heteroatom migration pathway and by the N2-C3 interchange reaction pathway. The latter route is enhanced by the addition of triethylamine (TEA) to the reaction medium and by increasing the polarity of the solvent. In addition to phototransposition, 5-phenylisothiazole also undergoes photocleavage to 2-cyano-1-phenylethenethiol which was trapped by reaction with benzyl bromide to yield 2-cyano-1-phenylethen-1-ylbenzyl thioether. 3-Phenylisothiazole also phototransposes by both reaction pathways, but the product distribution is not affected by the addition of TEA or by changing the solvent polarity.