- Ethyl 5-amino-3-oxo-1,2-dihydro-1h-pyrazole-1-carboxylate in the selective synthesis of partially hydrogenated pyrazolo[3,4-b]pyridin-3-ones
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Ethyl 5-amino-3-oxo-1,2-dihydro-1H-pyrazole-1-carboxylate undergoes selective cyclocondensation with 1,3-dicarbonyl compounds or their synthetic equivalents to give ethyl 3-oxo-1,2-dihydropyrazolo[3,4-b]pyridine-1- carboxylates which are readily converted
- Lebed,Mozgovaya,Kos,Vovk
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- AZOLOPYRIDIN-3-ONE DERIVATIVES AS INHIBITORS OF ENDOTHELIAL LIPASE
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The present invention relates to azolopyridin-3-one derivatives of the general formula (I) with the meanings indicated in the description, their pharmaceutically usable salts and their use as medicinal substances. The compounds are inhibitors of endotheli
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Page/Page column 51
(2008/06/13)
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- STUDIES IN THE FIELD OF NITROGEN HETEROCYCLIC COMPOUNDS. PART VII. CYCLOCONDENSATION OF ETHYL ACETOACETATE WITH 5-AMINO-3-PYRAZOLONE LEADING TO 5H,8H-1,5a,8a-TRIAZAACENAPHTHYLENE DERIVATIVES - NOVEL NITROGEN BRIDGEHEAD RING SYSTEM
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Cyclocondensation of 5-amino-3-pyrazolone (1) with ethyl acetoacetate (2) carried out in alkaline medium (pH ca. 10) led to formation of several products, depending upon the molar ratio of reagents used.Hitherto unknown ester 6, as well as two isomeric derivatives of novel bridgehead ring system, namely: 5H,8H-1,5a,8a-triazaacenaphthylene (B).The structures of the products result from their spectral data (1H NMR, MS) and some chemical transformations.Pathways of the formation of products are also discussed.
- Balicki, Roman
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p. 711 - 718
(2007/10/02)
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