- NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS
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The present disclosure is directed to novel compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.
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Page/Page column 53
(2012/01/05)
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- CYTIDINE ANALOGS AND METHODS OF USE
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Cytidine analogs, their prodrugs and/or metabolites are employed as pharmaceutically active compounds for treatment of diseases responsive to such compounds. Particularly preferred diseases include viral diseases (e.g., HCV infection) and neoplasms.
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Page/Page column 40
(2010/02/08)
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- Synthesis, base pairing, and fluorescence properties of oligonucleotides containing 1H-pyrazolo[3,4-d]pyrimidin-6-amine (8-aza-7-deazapurin-2-amine) as an analogue of purin-2-amine
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The synthesis of the N9- and N8-(β-D-2'-deoxyribonucleosides) 2 and 10, respectively, of 8-aza-7-deazapurin-2-amine (=1H-pyrazolo[3,4- d]pyrimidin-6-amine) is described. The fluorescence properties and the stability of the N-glycosylic bond of 2 were determined and compared with those of the 2'-deoxyribonucleosides 1 and 3 of purin-2-amine and 7- deazapurin-2-amine respectively. From the nucleoside 2, the phosphoramidite 14 was prepared, and oligonucleotides were synthesized. Duplexes containing compound 1 or 2 are slightly less stable than those containing 2'- deoxyadenosine, while their CD spectra are rather different. The fluorescence of the nucleosides is strongly quenched (>95%) in single-stranded as well as in duplex DNA. The residual fluorescence was used to determine the melting profiles, which gave T(m) values similar to those determined from the UV melting curves.
- Seela, Frank,Becher, Georg
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p. 928 - 942
(2007/10/03)
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