287177-82-6

Basic information

• Product Name: 1H-Pyrazolo[3,4-d]pyrimidin-6-amine (9CI)
• Synonyms: 1H-Pyrazolo[3,4-d]pyrimidin-6-amine (9CI);1H-pyrazolo[3,4-d]pyrimidin-6-amine
• CAS NO: 287177-82-6
• Molecular Formula: C5H5N5
• Molecular Weight: 135.1267
• Product Categories: PYRIMIDINE
• Mol File: 287177-82-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 482.41 °C at 760 mmHg
• Flash Point: 277.224 °C
• Appearance: /
• Density: 1.612 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.837
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1H-Pyrazolo[3,4-d]pyrimidin-6-amine (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazolo[3,4-d]pyrimidin-6-amine (9CI)(287177-82-6)
• EPA Substance Registry System: 1H-Pyrazolo[3,4-d]pyrimidin-6-amine (9CI)(287177-82-6)

Safety Data

• Hazardous Substances Data: 287177-82-6(Hazardous Substances Data)

Usage

General Description

1H-Pyrazolo[3,4-d]pyrimidin-6-amine (9CI) is a chemical compound with the molecular formula C7H6N6. It is a heterocyclic amine consisting of a pyrazolo-pyrimidine ring system. 1H-Pyrazolo[3,4-d]pyrimidin-6-amine (9CI) has potential applications in medicinal chemistry as a building block for the synthesis of biologically active molecules. It is also of interest in the field of organic synthesis and chemical research. The compound may have potential uses in the development of pharmaceuticals or as a reagent in chemical reactions. Its structure and properties make it a valuable tool for understanding and exploring the behavior of heterocyclic compounds in various applications.

InChI:InChI=1/C5H5N5/c6-5-7-1-3-2-8-10-4(3)9-5/h1-2H,(H3,6,7,8,9,10)

Upstream product

• 23002-51-9 6-chloro-1H-pyrazolo[3,4-d]pyrimidine 
• 871254-61-4 2,4-dichloro-5-pyrimidinecarboxaldehyde 
• 100644-65-3 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-6-amine 

Relevant articles and documents

NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS

The present disclosure is directed to novel compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.

Synthesis, base pairing, and fluorescence properties of oligonucleotides containing 1H-pyrazolo[3,4-d]pyrimidin-6-amine (8-aza-7-deazapurin-2-amine) as an analogue of purin-2-amine

The synthesis of the N9- and N8-(β-D-2'-deoxyribonucleosides) 2 and 10, respectively, of 8-aza-7-deazapurin-2-amine (=1H-pyrazolo[3,4- d]pyrimidin-6-amine) is described. The fluorescence properties and the stability of the N-glycosylic bond of 2 were determined and compared with those of the 2'-deoxyribonucleosides 1 and 3 of purin-2-amine and 7- deazapurin-2-amine respectively. From the nucleoside 2, the phosphoramidite 14 was prepared, and oligonucleotides were synthesized. Duplexes containing compound 1 or 2 are slightly less stable than those containing 2'- deoxyadenosine, while their CD spectra are rather different. The fluorescence of the nucleosides is strongly quenched (>95%) in single-stranded as well as in duplex DNA. The residual fluorescence was used to determine the melting profiles, which gave T(m) values similar to those determined from the UV melting curves.