Thiazolidinediones with thyroid hormone receptor agonistic activity
Several thiazolidinedione derivatives (3-7) were designed and synthesized as candidate thyromimetic drugs. Among them, the dihydrogenated compounds, such as 5-2-[[4-(3-tert-butyl-4-hydroxyphenyl)oxy-3,5- diiodophenyl]ethyl]-2,4-thiazolidine-dione (6b) and