Lithium-salt effects in peptide synthesis. Part I: Conditions for the use of lithium-salts in coupling reactions
The influence of Li-salts on the course of peptide-coupling reactions was investigated. As a model for segment couplings, Ac-Phe-OH was coupled to HCl . H-Ala-OMe using the mixed anhydride, DCCl, DCCl/HOBt, BOPCastro and TBTU-Knorr methods. As a model for