- 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoi c acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor α agonists
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Aromatic retinoids having a meta-substituted aromatic ring bridge, such as 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and its 3,5-diaryl-substituted 4,5-dihydroisoxazole analogue, function as retinoid receptor panagonists by activating both retinoic acid and retinoid X receptors to induce gene transcription, and thereby provide novel scaffolds for retinoid drug development. Both classes of these ligand-inducible transcription factors are involved in mediating the inhibitory effects of retinoids on cancer cell growth. (C) 2000 Elsevier Science Ltd. All rights reserved.
- Dawson, Marcia I.,Jong, Ling,Hobbs, Peter D.,Xiao, Dongmei,Feng, Kai-Chia,Chao, Wan-ru,Pan, Chin,Fontana, Joseph A.,Zhang, Xiao-kun
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