28921-30-4

Basic information

• Product Name: 1-(p-Chlorophenyl)-2-thioxo-2,3-dihydropyrimidine-4,6(1H,5H)-dione
• Synonyms: 1-(p-Chlorophenyl)-2-thioxo-2,3-dihydropyrimidine-4,6(1H,5H)-dione
• CAS NO: 28921-30-4
• Molecular Formula: C₁₀H₇ClN₂O₂S
• Molecular Weight: 0
• Mol File: 28921-30-4.mol

Chemical Properties

• Appearance: /
• Density: 1.57g/cm³
• Refractive Index: 1.705
• CAS DataBase Reference: 1-(p-Chlorophenyl)-2-thioxo-2,3-dihydropyrimidine-4,6(1H,5H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(p-Chlorophenyl)-2-thioxo-2,3-dihydropyrimidine-4,6(1H,5H)-dione(28921-30-4)
• EPA Substance Registry System: 1-(p-Chlorophenyl)-2-thioxo-2,3-dihydropyrimidine-4,6(1H,5H)-dione(28921-30-4)

Safety Data

• Hazardous Substances Data: 28921-30-4(Hazardous Substances Data)

Usage

Purpose

Medication used to treat gout and kidney stones

Mechanism of Action

Reduces the production of uric acid in the body

Enzyme Inhibition

Xanthine oxidase inhibitor

Enzyme Function

Inhibits the conversion of hypoxanthine to xantine and xanthine to uric acid

Effect on Uric Acid

Reduces levels of uric acid in the blood and urine

Prevention

Prevents the formation of gout crystals and kidney stones

Administration

Typically taken orally

Safety and Efficacy

Considered safe and effective when used as directed by a healthcare professional

InChI:InChI=1/C10H7ClN2O2S/c11-6-1-3-7(4-2-6)13-9(15)5-8(14)12-10(13)16/h1-4H,5H2,(H,12,14,16)

Upstream product

• 105-53-3 diethyl malonate 
• 3696-23-9 N-(4-chlorophenyl)thiourea 

Downstream Products

• 93084-97-0 2-[1-(4-Chloro-phenyl)-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-1-(4-methoxy-phenyl)-isothiourea; hydrochloride 
• 93110-21-5 2-[1-(4-Chloro-phenyl)-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-1-phenyl-isothiourea; hydrochloride 
• 93084-99-2 1-(4-Chloro-phenyl)-2-[1-(4-chloro-phenyl)-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-isothiourea; hydrochloride 
• 93084-98-1 1-(3-Chloro-phenyl)-2-[1-(4-chloro-phenyl)-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-isothiourea; hydrochloride 
• 93084-96-9 2-[1-(4-Chloro-phenyl)-4,6-dioxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-1-(3-methoxy-phenyl)-isothiourea; hydrochloride 

Relevant articles and documents

Chemical modification of plant alkaloids. 2. Reaction of cotarnine with barbituric acid derivatives and structure of 5-dihydrocotarnylbarbituric acids

The reaction of barbituric acid and its N-substituted derivatives and 2-thio analogs with cotarnine forms 5-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-2H-1,3-methylenedioxy-[4,5-g]isoquinolinyl-1)barbituric acids, a new class of zwitter-ions, the structure of which was studied by 1H and 13C NMR spectroscopy and mass spectrometry. The prepared compounds exist in solution as stable intermolecular associates and have a complicated H-bonded structure.