289630-03-1Relevant articles and documents
Sulphamethazine derivatives as immunomodulating agents: New therapeutic strategies for inflammatory diseases
Siddiqui, Hina,Haniffa, Haroon M.,Jabeen, Almas,Rahman, Atta-ur,Iqbal Choudhary
, (2019/01/03)
Sulfamethazine (SMZ) (1) is an antibacterial sulfa drug which suppresses the synthesis of dihydrofolic acid. It is used for the treatment of infections in livestock; such as gastrointestinal, and respiratory tract infections. During the current study, syn
Synthesis and biological evaluations of sulfa derivatives bearing heterocyclic moieties.
Abdel-Monem, Wafaa R
, p. 239 - 247 (2007/10/03)
Some new sulfa derivatives bearing a heterocyclic moieties fural, pyrimidinone, thiazolidinone, benzimidazole and 1,2,4-triazinone and the related compounds 2-19 have been synthesized from treatment of sulfa drugs with thioisocyanate, acid chlorides, 3-chloro-1,2,4-triazines, aldehydes, esters and/or 2-methylbenzoxazole followed by ring closure reactions. Structures of the products have been deduced from their elemental analysis and spectral data. Significant antimicrobial activities were observed in vitro for some members of the series. Compounds 9b, 16 are highly active, while compounds 4b, 6d, 7,9a, 10 and 14 showing a moderate active towards gramme positive bacterium (b.subtilis). gramme negative bacterium (E. coli) and two fungi namely (A.nidulans & A.terreus).