- New bicyclic antidepressant agent. Synthesis and activity of napactadine and related compounds
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A number of N,N'-dialkylarylamidines were synthesized and evaluated for antidepressan activity. Several of these compounds were synthesized from the corresponding nitriles by a new method. Slight structural modification in the series caused a marked chang
- McCarthy,Wright,Schuster,Abdallah,Shea,Eyster
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- Radical and Nitrenoid Reactivity of 3-Halo-3-phenyldiazirines
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3-Halo-3-phenyl-3H-diazirines (halogen = Br or Cl) undergo a dissociative single-electron transfer from alkyllithiums (RLi) in THF-based solvent mixtures. The resulting 3-phenyldiazirinyl radical, observed by EPR spectroscopy, is eventually transformed to benzonitrile. In Et2O, 2 equiv of RLi add to both nitrogens of halodiazirine N=N bond, affording N,N′-dialkylbenzamidines. The nitrenoid reactivity of some N-alkyl-1H-diazirine intermediates is manifested by their insertion into the α-C-H bond of THF or Et2O.
- Navrátil, Rafael,Tarábek, Ján,Linhart, Igor,Martin?, Tomá?
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supporting information
p. 3734 - 3737
(2016/08/16)
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- N,N′-Dimethylbenzamidine and derivatives: Preparations, structures, and hydrogen bond networks therein
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Reported herein are the syntheses of N,N′-dimethylbenzamidine (HDMBA, 1) and its phenyl substituted derivatives HYDMBA with phenyl substituents Y as 3-CH3O (2), and 3-CF3 (3), and the determination of single crystal structures of com
- Chen, Wei-Zhong,Xu, Guo-Lin,Jablonski, Conrad G.,Ren, Tong
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experimental part
p. 90 - 94
(2009/02/07)
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