290313-19-8 Usage
Uses
Used in Pharmaceutical Research:
4-CYCLOHEXYL-2-MERCAPTO-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE is utilized as a chemical entity in pharmaceutical research for its potential to contribute to the development of new drugs. Its unique molecular architecture allows it to interact with biological targets in ways that could lead to the creation of medicines for various diseases.
Used in Drug Development:
In the field of drug development, 4-CYCLOHEXYL-2-MERCAPTO-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE serves as a key compound for designing and synthesizing novel therapeutic agents. Its capacity to engage with specific biological pathways makes it a valuable asset in the quest to find cures or treatments for a range of medical conditions.
Used in Medicinal Chemistry:
4-CYCLOHEXYL-2-MERCAPTO-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE is applied in medicinal chemistry to explore its full potential in terms of biological activity. Further studies and research are essential to understand how this chemical can be harnessed to create effective and safe medications.
Used in Targeted Disease Treatment:
Although the specific diseases or biological pathways have not been detailed in the provided materials, the compound's potential for targeting specific diseases or pathways suggests that it could be used in the development of treatments for a variety of conditions. Its application would be as a component in the formulation of drugs designed to address particular health challenges.
Check Digit Verification of cas no
The CAS Registry Mumber 290313-19-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,0,3,1 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 290313-19:
(8*2)+(7*9)+(6*0)+(5*3)+(4*1)+(3*3)+(2*1)+(1*9)=118
118 % 10 = 8
So 290313-19-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H13N3OS/c12-6-8-9(7-4-2-1-3-5-7)13-11(16)14-10(8)15/h7H,1-5H2,(H2,13,14,15,16)
290313-19-8Relevant articles and documents
MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS)
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Paragraph 0149, (2013/08/28)
Embodiments of the invention are directed to compounds that inhibit an activity of EP AC proteins and methods of using the same. The inventors have developed a sensitive and robust high throughput screening (HTS) assay for the purpose of identifying EPAC specific inhibitors (Tsalkova et al. (2012) PLOS ONE 7(1 ):e30441).
5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP
Chen, Haijun,Tsalkova, Tamara,Mei, Fang C.,Hu, Yaohua,Cheng, Xiaodong,Zhou, Jia
scheme or table, p. 4038 - 4043 (2012/07/03)
Exchange proteins directly activated by cAMP (Epac) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. To explore the structural determinants for Epac antagonist properties of high throughput screening (HTS) hit ESI-08, pyrimidine 1, a series of 5-cyano-6-oxo-1,6-dihydro-pyrimidine analogues have been synthesized and evaluated for their activities for Epac inhibition. Structure-activity relationship (SAR) analysis led to the identification of three more potent Epac antagonists (6b, 6g, and 6h). These inhibitors may serve as valuable pharmacological probes for further elucidation of the physiological functions and mechanisms of Epac regulation. Our SAR results and molecular docking studies have also revealed that further optimization of the moieties at the C-6 position of pyrimidine scaffold may allow us to discover more potent Epac-specific antagonists.
