105-34-0Relevant articles and documents
Cyanidation of halogen compounds and esters catalyzed by PEG400 without solvent
Cao,Chen,Pei
, p. 2203 - 2207 (2001)
Primary aliphatic and aromatic nitriles were synthesized in excellent yields (84-96%) and purity by the cyanidation of halogen compounds and esters with dry powdered sodium cyanide catalysed by phase transfer catalyst PEG400 under solvent-free conditions.
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Gold,Waterman
, p. 40 (1967)
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The improved method of getting the cyano-aceticacid-methylester in good yield by the liquid-chromatography
Boki,Enomoto
, p. 544 - 548 (1969)
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Organic-inorganic hybrid supermicroporous iron(III) phosphonate nanoparticles as an efficient catalyst for the synthesis of biofuels
Pramanik, Malay,Bhaumik, Asim
, p. 8507 - 8514 (2013)
Here we report a novel family of crystalline, supermicroporous iron(III) phosphonate nanomaterials (HFeP-1-3, HFeP-1-2, and HFeP-1-4) with different FeIII-to-organophosphonate ligand mole ratios. The materials were synthesized by using a hydrothermal reaction between benzene-1,3,5-triphosphonic acid and iron(III) chloride under acidic conditions (pH≈4.0). Powder X-ray diffraction, N2 sorption, transmission and scanning electron microscopy (TEM and SEM) image analysis, thermogravimetric and differential thermal analysis (TGA-DTA), and FTIR spectroscopic tools were used to characterize the materials. The triclinic crystal phase [P1(2) space group] of the hybrid iron phosphonate was established by a Rietveld refinement of the PXRD analysis of HFeP-1-3 by using the MAUD program. The unit cell parameters are a=8.749(1), b=8.578(1), c=17.725(3) ?; α=104.47(3), β=97.64(1), γ=113.56(3)°; and V=1013.41 ?3. With these crystal parameters, we proposed an 24-membered-ring open framework structure for HFeP-1. Compound HFeP-1-3, with an starting Fe/ligand molar ratio of 3.0, shows the highest Brunauer-Emmett-Telller (BET) surface area of 556 m2g -1 and uniform supermicropores of approximately 1.1 nm. The acidic surface of the porous iron(III) phosphonate nanoparticles was used in a highly efficient and recyclable catalytic transesterification reaction for the synthesis of biofuels under mild reaction conditions. Iron brews biofuels: Highly crystalline, supermicroporous iron(III) phosphonate nanoparticles have been synthesized through a hydrothermal reaction between benzene-1,3,5- triphosphonic acid and FeCl3. The resulting material was used as an efficient and recyclable catalyst for the synthesis of biofuels under mild reaction conditions (see scheme). Copyright
Esterification of aryl/alkyl acids catalysed by n-bromosuccinimide under mild reaction conditions
?ebular, Klara,Bo?i?, Bojan ?.,Stavber, Stojan
, (2018)
N-halosuccinimides (NXSs) are well-known to be convenient, easily manipulable and low-priced halogenation reagents in organic synthesis. In the present work, N-bromosuccinimide (NBS) has been promoted as the most efficient and selective catalyst among the NXSs in the reaction of direct esterification of aryl and alkyl carboxylic acids. Comprehensive esterification of substituted benzoic acids, mono-, di- and tri-carboxy alkyl derivatives has been performed under neat reaction conditions. The method is metal-free, air- and moisture-tolerant, allowing for a simple synthetic and isolation procedure as well as the large-scale synthesis of aromatic and alkyl esters with yields up to 100%. Protocol for the recycling of the catalyst has been proposed.
Synthesis of DL 3 (3,4 dihydroxyphenyl)alanine methyl ester and related compounds
Damico,Nicholson
, p. 3057 - 3058 (1973)
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Organic-inorganic hybrid porous sulfonated zinc phosphonate material: Efficient catalyst for biodiesel synthesis at room temperature
Pramanik, Malay,Nandi, Mahasweta,Uyama, Hiroshi,Bhaumik, Asim
, p. 2273 - 2281 (2012)
A new porous zinc phosphonate material (HZnP-1) has been synthesized via the reaction between p-xylenediphosphonic acid and anhydrous ZnCl2 under hydrothermal and mildly acidic conditions (pH ～ 5) in the absence of any structure directing agent. The phenyl group of this material has been sulfonated with concentrated sulfuric acid to obtain sulfonic acid functionalized material HZnPS-1. Powder X-ray diffraction (XRD), field emission scanning electron microscopy (FE SEM), N2 sorption, solid state 13C CP MAS and 31P MAS NMR, and FT IR spectroscopic tools are employed to characterize these materials. The crystal structures of both the materials are indexed corresponding to the new orthorhombic phases with unit cell parameters a = 11.00, b = 8.74, c = 14.62 A, α = β = γ = 90° for HZnP-1, and a = 10.65, b = 13.52, c = 15.30 A and α = β = γ = 90° for HZnPS-1. HZnPS-1 showed outstanding catalytic activity and high recycling efficiency for the synthesis of different biodiesel compounds via esterification of long chain fatty acids by using methanol as both reactant and solvent at room temperature. The green and eco-friendly catalytic system described herein can overcome the problem faced by the existing catalytic systems known in biodiesel synthesis, such as drastic conditions (high reaction temperature) and requirement of hazardous organic solvents.
Facile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters
Ruan, Shixiang,Ruan, Jiancheng,Chen, Xinzhi,Zhou, Shaodong
, (2020/12/09)
The synthesis of nitrile under mild conditions was achieved via dehydration of primary amide using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only by-product, water from the system. Both aliphatic and aromatic nitriles can be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chemical calculations, and the crucial role the anionic ligand plays in the transformations were revealed.
BTK Inhibitors and uses thereof
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Paragraph 1771-1776, (2020/05/02)
The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.
