290332-99-9

Basic information

• Product Name: (4-METHOXY-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)METHANOL
• Synonyms: (4-METHOXY-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)METHANOL;(4-Methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)methanol ,99%;(4-Methoxy-7-azaindole-2-yl)methanol
• CAS NO: 290332-99-9
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.19
• Mol File: 290332-99-9.mol

Chemical Properties

• Appearance: /
• Density: 1.34g/cm³
• Refractive Index: 1.671
• CAS DataBase Reference: (4-METHOXY-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHOXY-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)METHANOL(290332-99-9)
• EPA Substance Registry System: (4-METHOXY-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)METHANOL(290332-99-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 290332-99-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C9H10N2O2/c1-13-8-2-3-10-9-7(8)4-6(5-12)11-9/h2-4,12H,5H2,1H3,(H,10,11)

Upstream product

• 290332-97-7 2-ethoxycarbonyl-4-methoxypyrrolo[2,3-b]pyridine 
• 82257-15-6 4-methoxynicotinaldehyde 
• 620-08-6 4-methoxypyridine 
• 290332-96-6 ethyl α-azido-β-(4-methoxypyrid-3-yl)acrylate 

Downstream Products

• 492438-80-9 5-acetyl-9-benzylamino-4-methoxy-6,7-dihydropyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 
• 492438-89-8 [5-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine 
• 492439-03-9 5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol 
• 492438-82-1 5-acetyl-9-benzylamino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 
• 492438-78-5 9-benzylamino-5-bromo-4-methoxy-6,7-dihydropyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 
• 492438-75-2 1-benzyl-3-[2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-ethyl]-urea 
• 492438-76-3 9-benzylamino-4-methoxy-6,7-dihydropyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine 
• 290333-01-6 2-formyl-4-methoxypyrrolo[2,3-b]pyridine 

Relevant articles and documents

AZAINDOLE COMPOUNDS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

PHOSPHOLIPASE INHIBITORS, INCLUDING MULTI-VALENT PHOSPHOLIPASE INHIBITORS, AND USE THEREOF, INCLUDING AS LUMEN-LOCALIZED PHOSPHOLIPASE INHIBITORS

The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.

Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

Carbodiimide-mediated preparation of the tricyclic pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine ring system and its application to the synthesis of the potent antitumoral marine alkaloid variolin B and analog

A total synthesis of the marine alkaloid variolin B has been completed in 13 steps in an overall yield of 6.5% from 3-formyl-4-methoxypyridine. Our approach is based on the sequential formation of the 7-azaindole ring, the tricyclic pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine ring system, and finally installation of the 2-aminopyrimidine ring at C5. The required 7-azaindole ring appropriately substituted is formed by a modified indole synthesis involving a nitrene insertion process (two steps). Formation of the annelated pyrimidine ring is achieved by two routes both involving a carbodiimide-mediated cyclization process, which allow incorporation of the amine functionality at C9 of the core tricyclic (six steps). Installation of the northeast 2-aminopyrimidine ring at C5 is performed using the Bredereck protocol (three steps). Ultimate, thermal decarboxylation with concomitant O-methyl deprotection and further N-benzyl deprotection by the action of triflic acid completed the synthesis of the target natural product variolin B.

Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin

A nine-step synthesis of 9-amino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2- c]pyrimidine, a tricyclic ring system present in the marine alkaloids variolins is described. The natural marine products meridianins C-E have been synthesized for the first time starting from N-protected 3-acylindoles. (C) 2000 Elsevier Science Ltd.