291514-04-0Relevant articles and documents
Design and synthesis of cyclic sulfonamides and sulfamates as new calcium sensing receptor agonists
Kiefer, Lionel,Gorojankina, Tatiana,Dauban, Philippe,Faure, Hélène,Ruat, Martial,Dodd, Robert H.
scheme or table, p. 7483 - 7487 (2011/02/21)
The design, synthesis and calcimimetic properties of various cyclic sulfonamides and sulfamates are described. The latter were prepared from the corresponding o-alkenylarenesulfonamides via copper- or rhodium-catalyzed intramolecular aziridination. The si
Efficient aziridination of olefins catalyzed by dirhodium catalysts
-
Page/Page column 13, (2010/11/23)
This invention relates to compositions and methods for achieving the efficient aziridination of organic molecules, especially olefins. More specifically, the invention is directed to a mild, selective, and efficient aziridination protocol that involves catalysis by a mixed-valent dirhodium(II,III) catalyst (Rh25+). Especially preferred sources for forming such mixed-valent dirhodium(II,III) catalyst (Rh25+) are dirhodium(II) carboxamidates, such as dirhodium(II) caprolactamate, and their derivatives and analogues.
Modulators of serotonin receptors
-
Page/Page column 74, (2010/02/11)
The present invention provides modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for exa
Rhodium(II)-catalyzed aziridination of allyl-substituted sulfonamides and carbamates
Padwa, Albert,Flick, Andrew C.,Leverett, Carolyn A.,Stengel, Thomas
, p. 6377 - 6386 (2007/10/03)
Several unsaturated sulfonamides underwent intramolecular aziridination when treated with PhI-(OAc)2, MgO, and catalytic Rh 2(OAc)4 to give bicyclic aziridines in excellent yield. Treatment of the resulting azabicyclic sul
Synthesis of cyclic sulfonamides via intramolecular copper-catalyzed reaction of unsaturated iminoiodinanes
Dauban, Philippe,Dodd, Robert H.
, p. 2327 - 2329 (2007/10/03)
(equation presented) Olefinic primary sulfonamides were treated with iodebenzene diacetate and potassium hydroxide in methanol to give intermediate iminoiodinanes. Catalytic copper(I) or (II) triflate then provided intramolecular nitrene delivery leading to aziridene formation except in one case where a rare copper-catalyzed C-H insertion was observed. The aziridines could be opened by various nucleophiles (methanol, thiophenol, allylmagnesium bromide, benzylamine) to give the corresponding substituted cyclic sulfonamides.