291514-18-6Relevant articles and documents
Carbazole-Containing Sulfonamides as Cryptochrome Modulators
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Paragraph 0355-0356, (2013/11/19)
The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.
Rhodium(II)-catalyzed aziridination of allyl-substituted sulfonamides and carbamates
Padwa, Albert,Flick, Andrew C.,Leverett, Carolyn A.,Stengel, Thomas
, p. 6377 - 6386 (2007/10/03)
Several unsaturated sulfonamides underwent intramolecular aziridination when treated with PhI-(OAc)2, MgO, and catalytic Rh 2(OAc)4 to give bicyclic aziridines in excellent yield. Treatment of the resulting azabicyclic sul
Synthesis of cyclic sulfonamides via intramolecular copper-catalyzed reaction of unsaturated iminoiodinanes
Dauban, Philippe,Dodd, Robert H.
, p. 2327 - 2329 (2007/10/03)
(equation presented) Olefinic primary sulfonamides were treated with iodebenzene diacetate and potassium hydroxide in methanol to give intermediate iminoiodinanes. Catalytic copper(I) or (II) triflate then provided intramolecular nitrene delivery leading to aziridene formation except in one case where a rare copper-catalyzed C-H insertion was observed. The aziridines could be opened by various nucleophiles (methanol, thiophenol, allylmagnesium bromide, benzylamine) to give the corresponding substituted cyclic sulfonamides.
