- Recent developments in the area of asymmetric transfer hydrogenation
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The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of α-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
- Wills, Martin,Palmer, Matthew,Smith, Athene,Kenny, Jennifer,Walsgrove, Tim
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- Asymmetric transfer hydrogenation of α-amino and α-alkoxy substituted ketones
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Through the use of appropriate protecting groups, the asymmetric transfer hydrogenation of ketones bearing heteroatoms at the α- position may be achieved in high yield and enantioselectivity.
- Kenny, Jennifer A.,Palmer, Matthew J.,Smith, Athene R. C.,Walsgrove, Tim,Wills, Martin
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p. 1615 - 1617
(2007/10/03)
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