291533-26-1Relevant articles and documents
Recent developments in the area of asymmetric transfer hydrogenation
Wills, Martin,Palmer, Matthew,Smith, Athene,Kenny, Jennifer,Walsgrove, Tim
, p. 4 - 18 (2000)
The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of α-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
Asymmetric transfer hydrogenation of α-amino and α-alkoxy substituted ketones
Kenny, Jennifer A.,Palmer, Matthew J.,Smith, Athene R. C.,Walsgrove, Tim,Wills, Martin
, p. 1615 - 1617 (2007/10/03)
Through the use of appropriate protecting groups, the asymmetric transfer hydrogenation of ketones bearing heteroatoms at the α- position may be achieved in high yield and enantioselectivity.
