GPR103 protein receptor inhibitor as well as preparation and application thereof
The invention provides a GPR103 protein receptor inhibitor as well as preparation and application thereof, and particularly provides a compound shown as a formula I or pharmaceutically acceptable salt thereof. The compound has excellent GPR103 protein inhibitory activity.
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Paragraph 0084; 0088
(2021/06/06)
A highly facile and efficient one-step synthesis of N6-adenosine and N6-2′-deoxyadenosine derivatives
(Chemical Equation Presented) A highly facile and efficient one-step synthesis of N6-adenosine and N6-2′-deoxyadenosine derivatives has been developed. Treatment of inosine or 2′-deoxyinosine, without protection of sugar hydroxyl groups, with alkyl or arylamines, in the presence of BOP and DIPEA in DMF, led to the formation of N6- adenosine and N6-2′-deoxyadenosine derivatives in good to excellent yields. Carcinogenic polyaromatic hydrocarbon (PAH) N 6-2′-deoxyadenosine adduct 10 and a rare DNA constituent 11 were thus synthesized directly from 2′-deoxyinosine both in 98% yield.
Wan, Zhao-Kui,Binnun, Eva,Wilson, Douglas P.,Lee, Jinbo
p. 5877 - 5880
(2007/10/03)
N6-phenyladenosines: Pronounced effect of phenyl substituents on affinity for A2 adenosine receptors
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Kwatra,Leung,Hosey,Green
p. 954 - 956
(2007/10/02)
Platelet aggregation inhibitors. 4. N 6 -substituted adenosines.
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Kikugawa,Iizuka,Ichino
p. 358 - 364
(2007/10/09)
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