- SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE DELTA INHIBITOR AND USE THEREOF
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The present invention belongs to the field of medicinal chemistry, and relates to substituted pyrimidine compounds as phosphatidylinositol 3-kinase (PI3K) δ inhibitor and a use thereof. In particular, the present invention provides a compound as shown by formula I or an isomer, pharmaceutically acceptable salt, solvate or prodrug thereof, the preparation methods of same and pharmaceutical compositions containing these compounds and a use of these compounds or compositions for treating cancer, hyperblastosis diseases or inflammatory diseases. The compounds of the present invention have a good inhibiting activity on PI3Kδ and have a high selectivity. It is hoped that these will be therapeutic agents for cancer, hyperblastosis diseases or inflammatory diseases.
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- Ru(II)-catalyzed C-H activation and annulation of salicylaldehydes with monosubstituted and disubstituted alkynes
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The Ru(ii)-catalyzed C-H activation and annulation reaction of salicylaldehydes and disubstituted alkynes affords chromones in high yields. This reaction also works with terminal alkynes and tolerates a wide range of sensitive functional groups. The selectivity pattern of this Ru(ii)-catalyzed annulation reaction is different from the known Au(i), Rh(iii)-catalyzed annulation reactions of salicylaldehydes and terminal alkynes.
- Baruah, Swagata,Kaishap, Partha Pratim,Gogoi, Sanjib
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supporting information
p. 13004 - 13007
(2016/11/11)
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- Unsymmetrical Bichromonyl Benzene Derivatives from Formyl Flavones
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New flavones (4b-f/6) with formyl functions in the 3-, 4'-, 6- and 4',6-positions are synthesized from bromomethyl or dibromomethyl flavone derivatives (3a-e) with methylflavones (2a-e) as starting compounds.The formyl flavones are suitable synthetic tool
- Wurm, Gotthard,Nordmann, Matthias
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p. 555 - 558
(2007/10/02)
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