29210-21-7

Usage

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 3083, 1973 DOI: 10.1016/S0040-4039(01)96325-7

InChI:InChI=1/C16H12O3/c17-10-13-15(18)12-8-4-5-9-14(12)19-16(13)11-6-2-1-3-7-11/h1-9,17H,10H2

Upstream product

• 50-00-0 formaldehyd 
• 1025-85-0 2,3-cis-3-Bromoflavanone 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 90-02-8 salicylaldehyde 
• 98-88-4 benzoyl chloride 
• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 118092-39-0 3-bromomethyl-2-phenyl-4H-chromen-4-one 
• 97139-84-9 2-benzoyloxypropiophenone 
• 71972-66-2 3-methyl-2-phenyl-4H-1-benzopyran-4-one 
• 29220-20-0 3-acetoxymethyl-2-phenyl-4H-chromen-4-one 

Relevant academic research and scientific papers

SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE DELTA INHIBITOR AND USE THEREOF

The present invention belongs to the field of medicinal chemistry, and relates to substituted pyrimidine compounds as phosphatidylinositol 3-kinase (PI3K) δ inhibitor and a use thereof. In particular, the present invention provides a compound as shown by formula I or an isomer, pharmaceutically acceptable salt, solvate or prodrug thereof, the preparation methods of same and pharmaceutical compositions containing these compounds and a use of these compounds or compositions for treating cancer, hyperblastosis diseases or inflammatory diseases. The compounds of the present invention have a good inhibiting activity on PI3Kδ and have a high selectivity. It is hoped that these will be therapeutic agents for cancer, hyperblastosis diseases or inflammatory diseases.

Ru(II)-catalyzed C-H activation and annulation of salicylaldehydes with monosubstituted and disubstituted alkynes

The Ru(ii)-catalyzed C-H activation and annulation reaction of salicylaldehydes and disubstituted alkynes affords chromones in high yields. This reaction also works with terminal alkynes and tolerates a wide range of sensitive functional groups. The selectivity pattern of this Ru(ii)-catalyzed annulation reaction is different from the known Au(i), Rh(iii)-catalyzed annulation reactions of salicylaldehydes and terminal alkynes.

Unsymmetrical Bichromonyl Benzene Derivatives from Formyl Flavones

New flavones (4b-f/6) with formyl functions in the 3-, 4'-, 6- and 4',6-positions are synthesized from bromomethyl or dibromomethyl flavone derivatives (3a-e) with methylflavones (2a-e) as starting compounds.The formyl flavones are suitable synthetic tool