293737-77-6Relevant articles and documents
Discovery and computational studies of 2-phenyl-benzoxazole acetamide derivatives as promising P2Y14R antagonists with anti-gout potential
Zhou, Mengze,Wang, Weiwei,Wang, Zhongkui,Wang, Yilin,Zhu, Yifan,Lin, Zhiqian,Tian, Sheng,Huang, Yuan,Hu, Qinghua,Li, Huanqiu
, (2021/10/25)
The P2Y14 nucleotide receptor, a subtype of P2Y receptors, is implicated in many human inflammatory diseases. Based on the identification of favorable residues of two screening hits in the almost symmetrical P2Y14 binding domain, we
Benzoxazole derivative as well as preparation method and application thereof (by machine translation)
-
Paragraph 0290-0293, (2020/03/29)
The invention provides a benzoxazole derivative as well as a preparation method and application, of the benzoxazole derivative as P. 2 Y14 The inhibitor has good inhibitory activity and anti-inflammatory activity, and further, by res
Small molecule inhibition of microRNA-21 expression reduces cell viability and microtumor formation
Ankenbruck, Nicholas,Kumbhare, Rohan,Naro, Yuta,Thomas, Meryl,Gardner, Laura,Emanuelson, Cole,Deiters, Alexander
supporting information, p. 3735 - 3743 (2019/07/03)
MicroRNAs (miRNAs) are short, non-coding RNA molecules estimated to regulate expression of a large number of protein-coding genes and are implicated in a variety of biological processes such as development, differentiation, proliferation, and cell surviva
Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition
Yeon Kim, Bo,Hee Yoon, Ji,Kim, Myeongbin,Nyoung Kim, Jae,Park, Hwangseo,Eon Ryu, Seong,Lee, Sangku
, p. 1746 - 1748 (2019/05/21)
Structure based virtual screening attempts to discover DUSP1 inhibitors have yielded a scaffold featuring benzoxazole and acylthiourea pharmacophore. A series of its analogues were synthesized to explore structure activity relationship (SAR) of DUSP1 inhi
BENZOXAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION
-
Page/Page column 40, (2008/06/13)
There is provided the use of a compound of formula (I),wherein Y, W1 to W4, Z1 to Z4 and R have meanings given in the description, and pharmaceutically-acceptable salts thereof, for the manufacture of a medicame
BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES USEFUL AS HEPARANASE INHIBITORS
-
Page 23-24, (2010/02/07)
Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7 R8, NR8COR10, NR8SO2R10 or C 1-6 alkyl optionally substituted by hydroxy, C 1-6 alkoxy or NR7R8; R4 is NR8CONR8R9; and R5 formula (Ia) is methods for their
2,3-Dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid derivatives: A novel class of small molecule heparanase inhibitors
Courtney, Stephen M.,Hay, Philip A.,Buck, Richard T.,Colville, Claire S.,Porter, David W.,Scopes, David I. C.,Pollard, Faye C.,Page, Martin J.,Bennett, James M.,Hircock, Margaret L.,McKenzie, Edward A.,Stubberfield, Colin R.,Turner, Paul R.
, p. 3269 - 3273 (2007/10/03)
A novel class of 2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acids are described as inhibitors of the endo-β-glucuronidase heparanase. Several of the compounds, for example, 2-[4-propylamino-5-[5-(4-chloro)phenyl-benzoxazol-2- yl]phenyl]-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid (9c), display potent heparanase inhibitory activity (IC50 200-500nM) and have high selectivity (>100-fold) over human β-glucuronidase. They also show anti-angiogenic effects. Such compounds should serve as useful biological tools and may provide a basis for the design of novel therapeutic agents.
PHTHALIMIDE CARBOXYLIC ACID DERIVATIVES
-
Page/Page column 16, (2008/06/13)
The present invention relates to phthalimide carboxylic acid derivatives of formula (I), methods for their preparation, pharmaceutical compositions containing them and their use in medicine, specifically in the treatment of cancer. (I), wherein X is O or S; R1 is a phthalimide carboxylic acid group of formula (II). R is hydrogen, C1-C6 alkyl, aryl or C1-C3 alkylaryl and R2, R3 and R4 represent various substituents.
