Synthesis of methylamino-2-phenyl-2-butyl-3,4,5-trimethoxybenzoate, the main bioactive metabolite of trimebutine maleate
The first synthesis of the methylamino-2-phenyl-2-butyl-3,4,5- trimethoxybenzoate (desmethyltrimebutine) I is described. This compound is the main bioactive metabolite of trimebutine II (Debridat, CAS 39133-31-8), an antispasmodic widely used for intestinal diseases since 1969. It was used for pharmacokinetic and bioequivalence studies.
Martin, Arnaud,Figadere, Bruno,Saivin, Sylvie,Houin, Georges,Chomard, Jean Marie,Cahiez, Gerard
p. 544 - 549
(2007/10/03)
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