296794-89-3

Basic information

• Product Name: 2-{5-[4-(methyloxy)phenyl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}-4-phenyl-1,3-thiazole
• Synonyms: 2-{5-[4-(methyloxy)phenyl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}-4-phenyl-1,3-thiazole
• CAS NO: 296794-89-3
• Molecular Formula: C25H21N3OS
• Molecular Weight: 411.51874
• Mol File: 296794-89-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-{5-[4-(methyloxy)phenyl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}-4-phenyl-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{5-[4-(methyloxy)phenyl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}-4-phenyl-1,3-thiazole(296794-89-3)
• EPA Substance Registry System: 2-{5-[4-(methyloxy)phenyl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}-4-phenyl-1,3-thiazole(296794-89-3)

Safety Data

• Hazardous Substances Data: 296794-89-3(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 153332-05-9 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole 
• 79-19-6 thiosemicarbazide 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 

Relevant articles and documents

Facile regioselective synthesis of novel bioactive thiazolyl-pyrazoline derivatives via a three-component reaction and their antimicrobial activity

A series of novel 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4- phenylthiazoles have been prepared by a three-component cyclo-condensation of various chalcones, thiosemicarbazide and phenacyl bromide. The easy work-up of the products, rapid reaction, and mild conditions are notable features of this protocol. The reaction was efficiently catalyzed in one-pot by a few drops of HCl in EtOH under reflux conditions providing the title compounds in moderate to high yields. The antibacterial activity of the selected products was examined. Some products exhibit promising activities.

Antioxidant capacity of 2-(3,5-diaryl-4,5-dihydro-1h-pyrazol-1-yl)-4- phenylthiazoles

The antioxidant capacity of 2-(3,5-diaryl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles was evaluated. The values of antioxidant capacities of compounds 2d and 2e were found to be, respectively, 2,700 ± 150 and 3,135 ± 230 TE by the ORAC method, correspo

Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity

Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds were performed by IR, 1H-NMR and Mass spectral data and elemental analyses. The hypotensive activities of 13 compounds were evaluated by using the tail-cuff method. All examined compounds showed appreciable hypotensive activities. Clonidine was used as reference substance in the pharmacological evaluation. (C) 2000 Editions scientifiques et medicales Elsevier SAS.