153332-05-9

Basic information

• Product Name: 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
• Synonyms: 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole
• CAS NO: 153332-05-9
• Molecular Weight: 311.407
• Mol File: 153332-05-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole(153332-05-9)
• EPA Substance Registry System: 1-thiocarbamoyl-5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazole(153332-05-9)

Safety Data

• Hazardous Substances Data: 153332-05-9(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 98-86-2 acetophenone 
• 79-19-6 thiosemicarbazide 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 10325-67-4 2,3-dibromo-3-(4-methoxy-phenyl)-1-phenyl-propan-1-one of mp: 140 degree 

Downstream Products

• 924864-03-9 2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one 
• 1018155-46-8 5-[2-(4-fluorophenyl)-2-oxoethyl]-2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]thiazol-4-one 
• 1018166-95-4 N-(4-acetoxyphenyl)-2-{2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1- yl]-4-oxo-4,5-dihydrothiazol-5-yl}acetamide 
• 929467-32-3 N-(4-methoxyphenyl)-2-{2-[5-(4-methoxyphenyl)-3- phenyl-4,5-dihydropyrazol-1-yl]-4- oxo- 4,5- dihydrothiazol- 5- yl}acetamide 
• 1402658-55-2 (3-{2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene}-2-oxo-2,3-dihydroindol-1-yl)acetic acid 
• 1018036-52-6 5-bromo-3-{2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene}-2,3-dihydro-1H-indol-2-one 
• 1018035-71-6 3-{2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl]-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene}-2,3-dihydro-1H-indol-2-one 
• 296794-89-3 2-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-phenylthiazole 
• 296794-90-6 5-methoxy-2-{2-[5-(4-methoxy-phenyl)-3-phenyl-4,5-dihydro-pyrazol-1-yl]-thiazol-4-yl}-phenol 
• 1278594-52-7 C₂₇H₂₁ClN₆OS 
• 1278594-53-8 C₂₈H₂₄N₆O₂S 

Relevant articles and documents

Synthesis, quantum chemical, in vitro acetyl cholinesterase inhibition and molecular docking studies of four new coumarin based pyrazolylthiazole nuclei

Four new 3-(2-(3-Phenyl-5-substituted phenyl-4,5-dihydropyrazol-1-yl)thiazol-4-yl)-2H-chromen-2-one derivatives (1–4) were synthesized and fully characterized by spectroscopic techniques. The final structures of all chromenone analogues (1–4) were confirm

Some thiocarbamoyl based novel anticathepsin agents

Cathepsins have emerged as important targets in various tissues degenerative disorders due to their involvement in degradation of extracellular matrices and endogenous protein turnover. Elevated cathepsins levels vis-à-vis decreased concentration of endogenous inhibitors has been reported at different diseased sites. The design and synthesis of specific potential anti-cathepsin agents is therefore of great significance. Most of potential anti-cathepsin agents developed have peptide based structures with an active warhead. Due to oral instability and immunogenic problems related to peptidyl inhibitors drift the synthesis and evaluation of non-peptide cathepsin inhibitors in last two decades. The present work provides a detailed structure activity relationship for developing potential non-peptide anticathepsin agents based on in-vitro inhibition studies of a library of synthesized thiocarbamoyl- non-peptide inhibitors.

Synergistic effect of pyrazoles derivatives and doxorubicin in claudin-low breast cancer subtype

Background Breast cancer is a global public health problem. For some subtypes, such as Claudin-low, the prognosis is poorer and the treatment is still a challenge. Pyrazoles are an important class of heterocyclic compounds and are promising anticancer age