296899-02-0 Usage
Uses
Used in Drug Discovery and Development:
1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid serves as a crucial component in the development of new pharmaceuticals. Its unique structure allows it to be a versatile building block for creating drug candidates that can target a variety of biological pathways and proteins. The presence of the bromophenyl group may facilitate the compound's interaction with specific biological targets, while the carboxylic acid group offers the potential for further chemical modifications to improve the compound's pharmacokinetic profile or targeting capabilities.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid is used as a key intermediate for the synthesis of diverse drug-like molecules. Researchers leverage the compound's structural features to explore its potential in modulating biological activities, leading to the discovery of new therapeutic agents. 1-(4-(4-BroMophenyl)thiazol-2-yl)piperidine-4-carboxylic acid's adaptability in chemical synthesis makes it a valuable tool for probing the structure-activity relationships of potential drugs.
Used in Targeting Specific Biological Pathways:
1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid is employed in the design of molecules that can selectively target and modulate specific biological pathways. The bromophenyl group's presence may enable the compound to engage with particular proteins or receptors, making it a promising candidate for the development of drugs that address specific therapeutic needs.
Used in Enhancing Pharmacokinetic Properties:
The carboxylic acid functionality of 1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid allows for the attachment of various chemical moieties, which can improve the compound's pharmacokinetic properties. This modification can lead to enhanced solubility, stability, absorption, distribution, metabolism, and excretion, ultimately contributing to the development of more effective and safer drugs.
Overall, 1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid is a valuable synthetic organic molecule with broad applications in the pharmaceutical and medicinal chemistry industries, particularly for the development of novel drug candidates and the enhancement of their therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 296899-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,6,8,9 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 296899-02:
(8*2)+(7*9)+(6*6)+(5*8)+(4*9)+(3*9)+(2*0)+(1*2)=220
220 % 10 = 0
So 296899-02-0 is a valid CAS Registry Number.
296899-02-0Relevant articles and documents
Discovery, synthesis, and biological evaluation of novel SMN protein modulators
Xiao, Jingbo,Marugan, Juan J.,Zheng, Wei,Titus, Steve,Southall, Noel,Cherry, Jonathan J.,Evans, Matthew,Androphy, Elliot J.,Austin, Christopher P.
supporting information; experimental part, p. 6215 - 6233 (2011/11/06)
Spinal muscular atrophy (SMA) is an autosomal recessive disorder affecting the expression or function of survival motor neuron protein (SMN) due to the homozygous deletion or rare point mutations in the survival motor neuron gene 1 (SMN1). The human genome includes a second nearly identical gene called SMN2 that is retained in SMA. SMN2 transcripts undergo alternative splicing with reduced levels of SMN. Up-regulation of SMN2 expression, modification of its splicing, or inhibition of proteolysis of the truncated protein derived from SMN2 have been discussed as potential therapeutic strategies for SMA. In this manuscript, we detail the discovery of a series of arylpiperidines as novel modulators of SMN protein. Systematic hit-to-lead efforts significantly improved potency and efficacy of the series in the primary and orthogonal assays. Structure-property relationships including microsomal stability, cell permeability, and in vivo pharmacokinetics (PK) studies were also investigated. We anticipate that a lead candidate chosen from this series may serve as a useful probe for exploring the therapeutic benefits of SMN protein up-regulation in SMA animal models and a starting point for clinical development.
ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION
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Page/Page column 51-52, (2011/11/01)
Aryl substituted thiazol-2-yl-piperidines and related compounds useful as modulators of survival motor neuron (SMN) protein production are provided herein. Without being bound to any particular theory it is believed the aryl substituted thiazol-2-yl-piper
