298204-37-2Relevant articles and documents
Stereoselective synthesis of hydroxylated β-aminocyclohexanecarboxylic acids
Kiss, Loránd,Forró, Eniko,Martinek, Tamás A.,Bernáth, Gábor,De Kimpe, Norbert,Fül?p, Ferenc
, p. 5036 - 5043 (2008/09/21)
A simple synthetic approach has been developed for the regio- and diastereoselective synthesis of hydroxylated 2-aminocyclohexanecarboxylic acid stereoisomers from 1,4-cyclohexadiene by the reductive opening of appropriate epoxide intermediates derived from the corresponding bicyclic β-lactams. This method has been extended to the synthesis of these hydroxylated β-amino acids in enantiomerically pure form.
Synthesis of 3- and 4-hydroxy-2-aminocyclohexanecarboxylic acids by lodocyclization
Szakonyi, Zsolt,Gyonfalvi, Szilvia,Forro, Enikoe,Hetenyi, Anasztazia,De Kimpe, Norbert,Fueloep, Ferenc
, p. 4017 - 4023 (2007/10/03)
Starting from cis-7-azabicyclo[4.2.0]oct-4-en-8-one, novel routes have been developed for the synthesis of 2-amino-4-hydroxycyclohexanecarboxylic acid and its 3-hydroxy-substituted analog via iodooxazine, iodooxazoline or iodolactone intermediates. After CAL-B-catalyzed enzymatic transformation of the starting β-lactam, the iodolactone method was applied to the synthesis of 3-hydroxy-substituted β-amino acid enantiomers. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
Facile regio- and diastereoselective syntheses of hydroxylated 2-aminocyclohexanecarboxylic acids
Fueloep, Ferenc,Palko, Marta,Forro, Eniko,Dervarics, Mate,Martinek, Tamas A.,Sillanpaeae, Reijo
, p. 3214 - 3220 (2007/10/03)
By means of total regio- and diastereoselective functionalizations of cis- and trans-2-amino-4-cyclohexenecarboxyric acid derivatives 1, 9, 12 and 16, isomers of 2-amino-4-hydroxycyclohexanecarboxylic acid 8 and 11, and 2-amino-5-hydroxycyclohexanecarboxy
