2998-56-3

Basic information

• Product Name: Bis(2-chloroethyl)carbamoyl chloride
• Synonyms: bis(2-chloroethyl)-carbamicchlorid;bis(2-chloroethyl)-carbamoylchlorid;bis(2-chloroethyl)carbamoylchloride;bischloroethylcarbamoylchloride;tl460;N,N-BIS(2-CHLOROETHYL)CARBAMOYL CHLORIDE;bis-(2-Chloroethyl)carbamic chloride;Bis-(2-chloro ethyl)carbamoyl hydrochloride
• CAS NO: 2998-56-3
• Molecular Formula: C₅H₈Cl₃NO
• Molecular Weight: 204.48
• EINECS: 221-075-8
• Mol File: 2998-56-3.mol

Chemical Properties

• Melting Point: 101-103 °C
• Boiling Point: 125°C 3mm
• Flash Point: 129.3 °C
• Appearance: Colorless transparent liquid
• Density: 1,4 g/cm3
• Refractive Index: 1.5060-1.5100
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -2.30±0.70(Predicted)
• CAS DataBase Reference: Bis(2-chloroethyl)carbamoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(2-chloroethyl)carbamoyl chloride(2998-56-3)
• EPA Substance Registry System: Bis(2-chloroethyl)carbamoyl chloride(2998-56-3)

Safety Data

• Hazard Codes: T
• Statements: 34-43-25
• Safety Statements: 26-36/37/39-45
• RIDADR: 3265
• RTECS: FD2200000
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 2998-56-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N,N-Bis(2-chloroethyl)carbamoyl chloride is used as an intermediate in the synthesis of cancer-fighting drugs for its alkylating properties, which can disrupt the replication of cancerous cells and contribute to the development of chemotherapeutic agents.
Used in Pesticide Industry:
In the pesticide industry, N,N-Bis(2-chloroethyl)carbamoyl chloride is used as a key component in the production of various pesticides, leveraging its alkylating capabilities to target and neutralize pests.

Upstream product

• 75-44-5 phosgene 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 503-38-8 trichloromethyl chloroformate 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 35875-89-9 bis-(2-chloro-ethyl)-carbamic acid methyl ester 
• 62899-48-3 Bis-(2-chloro-ethyl)-carbamic acid 4-[(E)-2-{4-[bis-(2-chloro-ethyl)-carbamoyloxy]-phenyl}-1-eth-(Z)-ylidene-but-2-enyl]-phenyl ester 
• 66919-79-7 N,N-Bis-<2-chloraethyl>-carbamoyl-L-phenylalanin-aethylester 
• 62899-53-0 C₂₅H₂₁Cl₂NO₆ 
• 24590-55-4 N_.N-Di-(2-chlorethyl)-sulfaminsaeurechlorid 
• 22794-66-7 1,1,3,3-Tetrakis-(2-chlorethyl)-ureid 
• 66919-75-3 N,N-Bis-(2-chlor-aethyl)-N'-aethoxycarbonylmethyl-harnstoff 
• 5467-16-3 Bis-<2-chlor-ethyl>-carbamidsaeure-butylester 
• 128349-68-8 E,Z-1-<4-(N,N-bis-β-chloroethylcarbamoyloxy)-phenyl>-1-(4-methoxyphenyl)-2-(3-methoxyphenyl)-but-1-ene 
• 110008-71-4 E,Z-1-<4-(N,N-bis-β-chloroethylcarbamoyloxy)-phenyl>-1,2-bis-(4-methoxyphenyl)-but-1-ene 
• 6548-19-2 2,2-Di<4-phenyl>propan 
• 6526-49-4 di-(2-chloroethyl)amino-4-nitrophenoxymethanone 
• 6526-84-7 Bis-(2-chloro-ethyl)-carbamic acid 4-(1-{4-[bis-(2-chloro-ethyl)-carbamoyloxy]-phenyl}-cyclohexyl)-phenyl ester 
• 6526-80-3 2,2-Di<4-phenyl>butan 

Relevant articles and documents

Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group

Most multi-action PtIV prodrugs have bioactive ligands containing carboxylates. This is probably due to the ease of carboxylating the OH axial ligands and because following reduction, the active drug is released. A major challenge is to expand the arsenal of bioactive ligands to include those without carboxylates. We describe a general approach for synthesis of PtIV prodrugs that release drugs with OH groups. We linked the OH groups of gemcitabine (Gem), paclitaxel (Tax), and estramustine (EM) to the PtIV derivative of cisplatin by a carbonate bridge. Following reduction, the axial ligands lost CO2, rapidly generating the active drugs. In contrast, succinate-linked drugs did not readily release the free drugs. The carbonate-bridged ctc-[Pt(NH3)2(PhB)(Gem-Carb)Cl2] was significantly more cytotoxic than the succinate-bridged ctc-[Pt(NH3)2(PhB)(Gem-Suc)Cl2], and more potent and less toxic than gemcitabine, cisplatin, and co-administration of cisplatin and gemcitabine.

Synthesis and characterization of glycosylated nitrogen mustard derivatives and their interaction with bovine serum albumin

To improve the specificity of nitrogen mustards towards tumor cells, glucose-nitrogen mustard, fructose-nitrogen mustard, and lactose-nitrogen mustard were prepared as three novel glycosylated nitrogen mustard derivatives by esterification of bis(2-chloro

ANTICANCER AGENTS

The invention generally concerns a method for conjugating an active material to a Pt complex.

Selective acylation process

This invention relates to a selective acylation process for the preparation of phenolic N-disubstituted carbamate esters of steroids, comprising reacting in an inert solvent an acylating agent being a carbamoyl halogenide, a 4-(tertiary amino)-pyridine, or a complex thereof, optionally as a part of a polymer and a steroid having at least two free hydroxy groups, where at least one is phenolic and at least one is alcoholic, optionally in the presence of an acid acceptor.

Certain steroid N-bis-(haloethyl)-carbamates

.Iadd.Antitumor active mono and poly N-Bis-(B-haloethyl)-carbamic acid esters of certain estrogenic steroid hormones, especially estradiol; such compounds wherein all hydroxyl groups of the steroid molecule are not thus esterified; and organic and inorganic acid esters of such latter compounds. .Iaddend.