cas 2998-56-3, N,N-Bis(2-chloroethyl)carbamoyl chloride

Articles about 2998-56-3Total 7 be found

Expanding the Arsenal of PtIV Anticancer Agents: Multi-action PtIV Anticancer Agents with Bioactive Ligands Possessing a Hydroxy Functional Group
Most multi-action PtIV prodrugs have bioactive ligands containing carboxylates. This is probably due to the ease of carboxylating the OH axial ligands and because following reduction, the active drug is released. A major challenge is to expand the arsenal of bioactive ligands to include those without carboxylates. We describe a general approach for synthesis of PtIV prodrugs that release drugs with OH groups. We linked the OH groups of gemcitabine (Gem), paclitaxel (Tax), and estramustine (EM) to the PtIV derivative of cisplatin by a carbonate bridge. Following reduction, the axial ligands lost CO2, rapidly generating the active drugs. In contrast, succinate-linked drugs did not readily release the free drugs. The carbonate-bridged ctc-[Pt(NH3)2(PhB)(Gem-Carb)Cl2] was significantly more cytotoxic than the succinate-bridged ctc-[Pt(NH3)2(PhB)(Gem-Suc)Cl2], and more potent and less toxic than gemcitabine, cisplatin, and co-administration of cisplatin and gemcitabine.
Yempala, Thirumal,Babu, Tomer,Karmakar, Subhendu,Nemirovski, Alina,Ishan, Maisaloon,Gandin, Valentina,Gibson, Dan
p. 18218 - 18223
(2019)
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Synthesis and characterization of glycosylated nitrogen mustard derivatives and their interaction with bovine serum albumin
To improve the specificity of nitrogen mustards towards tumor cells, glucose-nitrogen mustard, fructose-nitrogen mustard, and lactose-nitrogen mustard were prepared as three novel glycosylated nitrogen mustard derivatives by esterification of bis(2-chloro
Li, Shan,Li, He-Ping,Qin, Long
p. 1949 - 1956
(2013)
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ANTICANCER AGENTS
The invention generally concerns a method for conjugating an active material to a Pt complex.
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Page/Page column 27; 33; 34

(2021/02/12)

Selective acylation process
This invention relates to a selective acylation process for the preparation of phenolic N-disubstituted carbamate esters of steroids, comprising reacting in an inert solvent an acylating agent being a carbamoyl halogenide, a 4-(tertiary amino)-pyridine, or a complex thereof, optionally as a part of a polymer and a steroid having at least two free hydroxy groups, where at least one is phenolic and at least one is alcoholic, optionally in the presence of an acid acceptor.
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(2008/06/13)

Certain steroid N-bis-(haloethyl)-carbamates
.Iadd.Antitumor active mono and poly N-Bis-(B-haloethyl)-carbamic acid esters of certain estrogenic steroid hormones, especially estradiol; such compounds wherein all hydroxyl groups of the steroid molecule are not thus esterified; and organic and inorganic acid esters of such latter compounds. .Iaddend.
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(2008/06/13)

N,N-Bis-(2-chlorethyl)-sulfamic acid derivatives. 4. Chlorine cleavability and biological activity in N-lost compounds.
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PREUSSMANN
p. 1119 - 1123
(2007/10/06)