301308-88-3

Basic information

• Product Name: N-(4-ethylphenyl)methanesulfonamide
• Synonyms: N-(4-ethylphenyl)methanesulfonamide
• CAS NO: 301308-88-3
• Molecular Formula: C₉H₁₃NO₂S
• Molecular Weight: 199.27002
• Mol File: 301308-88-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-ethylphenyl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-ethylphenyl)methanesulfonamide(301308-88-3)
• EPA Substance Registry System: N-(4-ethylphenyl)methanesulfonamide(301308-88-3)

Safety Data

• Hazardous Substances Data: 301308-88-3(Hazardous Substances Data)

Upstream product

• 97-94-9 triethyl borane 
• 4284-50-8 N-(4-bromophenyl)methanesulfonamide 
• 124-63-0 methanesulfonyl chloride 
• 589-16-2 4-aminoethylbenzene 

Downstream Products

• 1188925-35-0 N-(4-ethyl-4-methoxycyclohexa-2,5-dien-1-ylidene)methanesulfonamide 

Relevant articles and documents

Soft-Hard Acid/Base-Controlled, Oxidative, N-Selective Arylation of Sulfonanilides via a Nitrenium Ion

In iodine(III)-catalyzed, dehydrogenative arylations of sulfonanilides, the functionalization of C-C bonds is preferred over the functionalization of C-N bonds. Herein, an unprecedented N-selective arylation of sulfonanilides using soft-hard acid-base (SHAB) control by a nitrenium ion over a carbenium ion is reported. Treatment of sulfonanilides with iodine(III) led to the formation of nitrenium ions (soft), which preferentially react with biphenyls (soft) over bimesityl (hard) to generate C-N bonds. The iodine(III) was generated in situ by using PhI and mCPBA at room temperature.

An Organic Intermolecular Dehydrogenative Annulation Reaction

The discovery of a direct method for the synthesis of three-ring heterocyclic carbazoles from unactivated arenes and anilides by a metal-free (organic) intermolecular dehydrogenative annulation reaction under ambient laboratory conditions is reported. Iodine(III) was used as the sole reagent either stoichiometrically from inexpensive phenyliodine diacetate or organocatalytically by in situ generation from PhI-mCPBA. In a single step, three C(sp2)-H bonds and one N(sp3)-H bond are functionalized from two different arenes for tandem C-C and C-N bond formation reactions.

B-Alkyl Suzuki-Miyaura cross-coupling of tri-n-alkylboranes with arylbromides bearing acidic functions under mild non-aqueous conditions

An efficient and chemoselective Pd-catalyzed B-alkyl Suzuki-Miyaura cross-coupling of tri-n-alkylboranes with arylbromides possessing acidic functions is described. This protocol features the relatively weak base Cs2CO3 and mild non-

Direct B-alkyl Suzuki-Miyaura cross-coupling of trialkyl-boranes with aryl bromides in the presence of unmasked acidic or basic functions and base-labile protections under mild non-aqueous conditions

An efficient and chemoselective palladium-catalyzed direct B-alkyl Suzuki-Miyaura cross-coupling of trialkylboranes with diversely functionalized aryl bromides is described. A wide variety of unmasked acidic or basic functions are tolerated. The mild non-